MechRegistry
A registry of Mechs: AI agent-curated knowledge bases.

A Mech keeps one validated, ontology-grounded, evidence-backed record per entity, with a LinkML schema and an append-only curation history. AI agents write most of it and people review it. The canonical Mech is DisMech. What is a Mech?

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Mechs

Active

1097459

Records, summed

Record counts were last refreshed on 2026-10-13. The oldest is from 2026-10-12. Counts are refreshed weekly from each Mech's repository.

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Domain

Collection

Status

Maturity

Ontology

Mech	One record is	Records	Domains	Ontologies	Status	License
ai-gene-review ai-gene-review is an agent-curated knowledge base of Gene Ontology annotation reviews. One record per gene product: each record takes every existing GO annotation for the gene from GOA...	a gene product and the review of its existing GO annotations	6760 2026-10-12	genomics biological systems pathways organisms	GO ECO NCBITaxon	active curating	BSD 3-Clause License
AIMech AIMech extends the Mech curation workflow from biology to artificial intelligence. One record is one AI concept: a model, layer, training strategy, task, bias or the like. It...	an artificial intelligence concept	1088 2026-10-13	machine learning information technology	AIO BFO	active curating	CC BY 4.0
AntibioticMech AntibioticMech is a knowledge base of individual chemical structures with antimicrobial activity, harmonized from ChEBI and CARD's Antibiotic Resistance Ontology. One record is one chemical structure, keyed by...	an antimicrobial chemical structure	2939 2026-10-12	chemistry and biochemistry pharmacology microbiology	CHEBI ARO CAS PubChem DrugBank NCBITaxon	active curating	CC BY 4.0
CellStructureMech CellStructureMech is a knowledge base of microbial cell structures: organelles, envelope layers, appendages, microcompartments, inclusions, cytoskeletal systems and the multi-protein complexes that build them. One record is a...	a microbial cell structure or multi-protein complex	909 2026-10-12	microbiology biological systems anatomy and development	GO NCBITaxon UniProt METPO Pfam PDB	active curating	CC0 1.0
CMMMech CMMMech is a knowledge base of critical minerals and materials and the microbial mechanisms that extract, transform or recover them. One record is one material: an element, a...	a critical mineral, element or secondary resource	278 2026-10-13	microbiology chemistry and biochemistry environment	CHEBI NCBITaxon	active curating	CC BY 4.0
CommunityMech CommunityMech is a knowledge base of microbial communities: their composition, ecological interactions, cultivation conditions, environments and supporting evidence. Curated YAML is the canonical record format. Validation, the static...	a microbial community	458 2026-10-12	microbiology environment organisms	NCBITaxon CHEBI GO ENVO GTDB	active curating	CC0 1.0
CultureMech CultureMech is a versioned knowledge base of microbial culture-media recipes from MediaDive, TogoMedium, KOMODO and the major culture collections. It combines LinkML validation, ontology grounding, provenance, deduplication, browser...	a culture-medium recipe	6320 2026-10-12	microbiology nutrition chemistry and biochemistry	CHEBI KEGG FOODON UBERON CAS NCBITaxon	active curating	CC0 1.0
DisMech DisMech, the Disorder Mechanisms Knowledge Base, is a structured, evidence-backed knowledge base of disease pathophysiology. It records how diseases work: the cell types, biological processes and causal chains...	a human disorder or disorder subtype	3358 2026-10-12	biomedical clinical phenotype pathways genomics	MONDO HP GO CL UBERON NCIT +5	active curating	CC BY 4.0
DUFMech DUFMech is a knowledge base of protein domains of unknown function. One record is one Pfam family whose public InterPro metadata still reads like a domain or protein...	a Pfam domain family of unknown function	8296 2026-10-13	genomics microbiology	Pfam InterPro UniProt PDB	active seeded	CC BY 4.0
HabitatMech HabitatMech is a knowledge base of microbial habitats and environments. Four source vocabularies that describe where microbes are found, JGI GOLD ecosystem paths, BacDive isolation sources, PREGO ontology...	a microbial habitat or environment	3208 2026-10-12	microbiology environment	ENVO UBERON FOODON BTO NCBITaxon	active curating	CC0 1.0
KG-Registry KG-Registry is a registry of knowledge graphs and the resources they are built from: data sources, ontologies, data models and aggregators. One record per resource: each record holds...	a knowledge resource (knowledge graph, data source, ontology, data model or aggregator) and its products	1137 2026-10-12	biomedical	NCBITaxon MESH NCIT	active curating	CC0 1.0
MediaIngredientMech MediaIngredientMech is an LLM-assisted curation system for culture-media ingredient ontology mappings, with full audit trails. It manages the ingredient records aggregated from media recipes in CultureMech and owns...	a culture-media ingredient	2953 2026-10-12	chemistry and biochemistry nutrition microbiology	CHEBI CAS NCIT FOODON ENVO MESH	active curating	CC0 1.0
NaturalProductMech NaturalProductMech is a knowledge base of individual natural product structures. One record is one chemical structure made by a living organism, carrying who makes it, from which biosynthetic...	a natural product chemical structure	3115 2026-10-12	chemistry and biochemistry microbiology pathways	CHEBI NCBITaxon MIBiG NPAtlas PubChem UniProt	active seeded	CC BY 4.0
PathwayMech PathwayMech is a knowledge base of pathway-level microbial mechanisms. One record is one pathway, held as a small graph: named participants, reactions, and causal edges between them, each...	a microbial pathway mechanism	242 2026-10-13	pathways microbiology chemistry and biochemistry	CHEBI RHEA UniProt GO RO ECO +1	active curating	CC BY 4.0
ProteinTraitsMech ProteinTraitsMech is a knowledge base of protein sequence, structure, function and evolution traits, one YAML record per trait with optional evidence-backed causal graphs. Traits run along five axes:...	a protein sequence, structure, function or evolution trait class	429293 2026-10-12	biological systems chemistry and biochemistry genomics	InterPro Pfam UniProt Rhea GO CHEBI +6	active seeded	CC0 1.0
SOMAMech SOMAMech is a paper-extraction knowledge base for environmental health sciences. It curates publications on PM2.5, smoke and other inhaled exposures and their effects on airway biology into data...	a publication, extracted into its assays, measurements and Key Events	40 2026-10-12	environment biomedical phenotype biological systems	CHEBI GO CL UBERON HP PATO +10	active curating	MIT License
TaxonMech TaxonMech is a knowledge base of microbial taxa and the strains behind them. One record per taxon, keyed by NCBI Taxonomy and harmonized with GTDB, LPSN, BacDive, MediaDive,...	a microbial taxon at species rank or below	625960 2026-10-12	microbiology organisms genomics	NCBITaxon GTDB BacDive GOLD insdc.gca refseq +4	active seeded	CC0 1.0
TraitMech TraitMech is a knowledge base of microbial ecophysiological traits, seeded from METPO, the Microbial Ecophysiological Trait and Phenotype Ontology, and curated incrementally. Each trait, such as Gram type,...	a microbial ecophysiological trait	1105 2026-10-12	microbiology phenotype	METPO GO NCBITaxon CHEBI UniProt PATO	active reviewed	CC0 1.0

MechRegistry A registry of Mechs: AI agent-curated knowledge bases.

MechRegistry
A registry of Mechs: AI agent-curated knowledge bases.