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Class: CellLineModel

A model system based on immortalized cell lines that can be maintained in culture indefinitely. Examples: HepG2, A549, Caco-2, etc.

URI: [namo:CellLineModel](https://w3id.org/monarch-initiative/namo/CellLineModel)
classDiagram class CellLineModel click CellLineModel href "../CellLineModel/" TwoDCellCulture <|-- CellLineModel click TwoDCellCulture href "../TwoDCellCulture/" CellLineModel : authentication_method CellLineModel : biological_organization_level CellLineModel --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" CellLineModel : cell_source CellLineModel : cell_types CellLineModel --> "*" Cell : cell_types click Cell href "../Cell/" CellLineModel : complexity_level CellLineModel --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" CellLineModel : confluence_level CellLineModel : culture_conditions CellLineModel : description CellLineModel : id CellLineModel : models CellLineModel --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" CellLineModel : name CellLineModel : passage_protocol CellLineModel : passage_range CellLineModel : references CellLineModel --> "*" Reference : references click Reference href "../Reference/" CellLineModel : spatial_context CellLineModel : substrate_type CellLineModel : type
## Inheritance * [NamedThing](NamedThing.md) * [ModelSystem](ModelSystem.md) * [NAMModel](NAMModel.md) * [CellularSystem](CellularSystem.md) * [TwoDCellCulture](TwoDCellCulture.md) * **CellLineModel** ## Slots | Name | Cardinality and Range | Description | Inheritance | | --- | --- | --- | --- | | [passage_range](passage_range.md) | 0..1
[String](String.md) | Recommended passage number range for experimental use | direct | | [authentication_method](authentication_method.md) | 0..1
[String](String.md) | Method used for cell line authentication (e | direct | | [substrate_type](substrate_type.md) | 0..1
[String](String.md) | Type of culture substrate (e | [TwoDCellCulture](TwoDCellCulture.md) | | [confluence_level](confluence_level.md) | 0..1
[Float](Float.md) | Typical confluence level maintained (0 | [TwoDCellCulture](TwoDCellCulture.md) | | [passage_protocol](passage_protocol.md) | 0..1
[String](String.md) | Standard passaging protocol and frequency | [TwoDCellCulture](TwoDCellCulture.md) | | [cell_types](cell_types.md) | *
[Cell](Cell.md) | Cell types present in the cellular system | [CellularSystem](CellularSystem.md) | | [cell_source](cell_source.md) | 0..1
[String](String.md) | Source of cells (e | [CellularSystem](CellularSystem.md) | | [culture_conditions](culture_conditions.md) | 0..1
[String](String.md) | Standard culture conditions and media used | [CellularSystem](CellularSystem.md) | | [biological_organization_level](biological_organization_level.md) | 0..1
[BiologicalOrganizationLevelEnum](BiologicalOrganizationLevelEnum.md) | The level of biological organization represented by the model | [NAMModel](NAMModel.md) | | [spatial_context](spatial_context.md) | 0..1
[String](String.md) | Description of spatial organization and context captured by the model | [NAMModel](NAMModel.md) | | [complexity_level](complexity_level.md) | 0..1
[ComplexityLevelEnum](ComplexityLevelEnum.md) | Level of biological complexity represented (subcellular, cellular, tissue, or... | [NAMModel](NAMModel.md) | | [references](references.md) | *
[Reference](Reference.md) | Literature references that describe, validate, or support this model | [NAMModel](NAMModel.md) | | [models](models.md) | *
[ModelsRelationship](ModelsRelationship.md) | | [ModelSystem](ModelSystem.md) | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | A unique identifier for a thing | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | A human-readable name for a thing | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | A human-readable description for a thing | [NamedThing](NamedThing.md) | | [type](type.md) | 0..1
[String](String.md) | | [NamedThing](NamedThing.md) | ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/monarch-initiative/namo ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | namo:CellLineModel | | native | namo:CellLineModel | ## LinkML Source ### Direct 
name: CellLineModel
description: 'A model system based on immortalized cell lines that can be maintained
  in culture indefinitely. Examples: HepG2, A549, Caco-2, etc.'
from_schema: https://w3id.org/monarch-initiative/namo
is_a: TwoDCellCulture
attributes:
  passage_range:
    name: passage_range
    description: Recommended passage number range for experimental use
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CellLineModel
  authentication_method:
    name: authentication_method
    description: Method used for cell line authentication (e.g., STR profiling, mycoplasma
      testing)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CellLineModel
### Induced 
name: CellLineModel
description: 'A model system based on immortalized cell lines that can be maintained
  in culture indefinitely. Examples: HepG2, A549, Caco-2, etc.'
from_schema: https://w3id.org/monarch-initiative/namo
is_a: TwoDCellCulture
attributes:
  passage_range:
    name: passage_range
    description: Recommended passage number range for experimental use
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - CellLineModel
    range: string
  authentication_method:
    name: authentication_method
    description: Method used for cell line authentication (e.g., STR profiling, mycoplasma
      testing)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - CellLineModel
    range: string
  substrate_type:
    name: substrate_type
    description: Type of culture substrate (e.g., plastic, glass, coated surfaces)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - TwoDCellCulture
    range: string
  confluence_level:
    name: confluence_level
    description: Typical confluence level maintained (0.0-1.0)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - TwoDCellCulture
    range: float
  passage_protocol:
    name: passage_protocol
    description: Standard passaging protocol and frequency
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - TwoDCellCulture
    range: string
  cell_types:
    name: cell_types
    description: Cell types present in the cellular system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: Cell
    bindings:
    - range: CellTypeEnum
      obligation_level: REQUIRED
      binds_value_of: id
    multivalued: true
    inlined: true
    inlined_as_list: true
  cell_source:
    name: cell_source
    description: Source of cells (e.g., primary, iPSC-derived, immortalized cell lines)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: string
  culture_conditions:
    name: culture_conditions
    description: Standard culture conditions and media used
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - CellularSystem
    range: string
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CellLineModel
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    owner: CellLineModel
    domain_of:
    - NamedThing
    - Reference
    - BiolinkEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    owner: CellLineModel
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    owner: CellLineModel
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    owner: CellLineModel
    domain_of:
    - NamedThing
    range: string