Class: CoCulture

Co-culture systems combining multiple cell types to mimic microenvironments and cell-cell interactions.

classDiagram class CoCulture click CoCulture href "../CoCulture/" CellularSystem <|-- CoCulture click CellularSystem href "../CellularSystem/" CoCulture : biological_organization_level CoCulture --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" CoCulture : cell_ratios CoCulture --> "*" CellRatio : cell_ratios click CellRatio href "../CellRatio/" CoCulture : cell_source CoCulture : cell_types CoCulture --> "*" Term : cell_types click Term href "../Term/" CoCulture : coculture_configuration CoCulture --> "0..1" CocultureConfigurationEnum : coculture_configuration click CocultureConfigurationEnum href "../CocultureConfigurationEnum/" CoCulture : complexity_level CoCulture --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" CoCulture : culture_conditions CoCulture : description CoCulture : id CoCulture : interaction_mechanisms CoCulture : models CoCulture --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" CoCulture : name CoCulture : references CoCulture --> "*" Reference : references click Reference href "../Reference/" CoCulture : spatial_context CoCulture : type

Inheritance

NamedThing
- ModelSystem
  - NAMModel
    - CellularSystem
      - CoCulture

Slots

Name	Cardinality and Range	Description	Inheritance
coculture_configuration	0..1 CocultureConfigurationEnum	Configuration of co-culture (direct contact, transwell, conditioned media)	direct
cell_ratios	* CellRatio	Ratios of different cell types in the co-culture	direct
interaction_mechanisms	* String	Mechanisms of cell-cell interaction (paracrine, direct contact, mechanical)	direct
cell_types	* Term	Cell types present in the cellular system	CellularSystem
cell_source	0..1 String	Source of cells (e	CellularSystem
culture_conditions	0..1 String	Standard culture conditions and media used	CellularSystem
biological_organization_level	0..1 BiologicalOrganizationLevelEnum	The level of biological organization represented by the model	NAMModel
spatial_context	0..1 String	Description of spatial organization and context captured by the model	NAMModel
complexity_level	0..1 ComplexityLevelEnum	Level of biological complexity represented (subcellular, cellular, tissue, or...	NAMModel
references	* Reference	Literature references that describe, validate, or support this model	NAMModel
models	* ModelsRelationship		ModelSystem
id	1 Uriorcurie	A unique identifier for a thing	NamedThing
name	0..1 String	A human-readable name for a thing	NamedThing
description	0..1 String	A human-readable description for a thing	NamedThing
type	0..1 String		NamedThing

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/monarch-initiative/namo

Mappings

Mapping Type	Mapped Value
self	namo:CoCulture
native	namo:CoCulture

LinkML Source

Direct

name: CoCulture
description: Co-culture systems combining multiple cell types to mimic  microenvironments
  and cell-cell interactions.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: CellularSystem
attributes:
  coculture_configuration:
    name: coculture_configuration
    description: Configuration of co-culture (direct contact, transwell, conditioned
      media)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CoCulture
    range: CocultureConfigurationEnum
  cell_ratios:
    name: cell_ratios
    description: Ratios of different cell types in the co-culture
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CoCulture
    range: CellRatio
    multivalued: true
    inlined: true
    inlined_as_list: true
  interaction_mechanisms:
    name: interaction_mechanisms
    description: Mechanisms of cell-cell interaction (paracrine, direct contact, mechanical)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CoCulture
    multivalued: true

Induced

name: CoCulture
description: Co-culture systems combining multiple cell types to mimic  microenvironments
  and cell-cell interactions.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: CellularSystem
attributes:
  coculture_configuration:
    name: coculture_configuration
    description: Configuration of co-culture (direct contact, transwell, conditioned
      media)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: coculture_configuration
    owner: CoCulture
    domain_of:
    - CoCulture
    range: CocultureConfigurationEnum
  cell_ratios:
    name: cell_ratios
    description: Ratios of different cell types in the co-culture
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: cell_ratios
    owner: CoCulture
    domain_of:
    - CoCulture
    range: CellRatio
    multivalued: true
    inlined: true
    inlined_as_list: true
  interaction_mechanisms:
    name: interaction_mechanisms
    description: Mechanisms of cell-cell interaction (paracrine, direct contact, mechanical)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: interaction_mechanisms
    owner: CoCulture
    domain_of:
    - CoCulture
    range: string
    multivalued: true
  cell_types:
    name: cell_types
    description: Cell types present in the cellular system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: cell_types
    owner: CoCulture
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: Term
    bindings:
    - range: CellTypeEnum
      obligation_level: REQUIRED
      binds_value_of: id
    multivalued: true
    inlined: true
    inlined_as_list: true
  cell_source:
    name: cell_source
    description: Source of cells (e.g., primary, iPSC-derived, immortalized cell lines)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: cell_source
    owner: CoCulture
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: string
  culture_conditions:
    name: culture_conditions
    description: Standard culture conditions and media used
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: culture_conditions
    owner: CoCulture
    domain_of:
    - CellularSystem
    range: string
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: biological_organization_level
    owner: CoCulture
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: spatial_context
    owner: CoCulture
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: complexity_level
    owner: CoCulture
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: references
    owner: CoCulture
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: models
    owner: CoCulture
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    alias: id
    owner: CoCulture
    domain_of:
    - NamedThing
    - Reference
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: CoCulture
    domain_of:
    - NamedThing
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: CoCulture
    domain_of:
    - NamedThing
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    alias: type
    owner: CoCulture
    domain_of:
    - NamedThing
    range: string