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Class: CoCulture

Co-culture systems combining multiple cell types to mimic microenvironments and cell-cell interactions.

URI: [namo:CoCulture](https://w3id.org/monarch-initiative/namo/CoCulture)
classDiagram class CoCulture click CoCulture href "../CoCulture/" CellularSystem <|-- CoCulture click CellularSystem href "../CellularSystem/" CoCulture : biological_organization_level CoCulture --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" CoCulture : cell_ratios CoCulture --> "*" CellRatio : cell_ratios click CellRatio href "../CellRatio/" CoCulture : cell_source CoCulture : cell_types CoCulture --> "*" Cell : cell_types click Cell href "../Cell/" CoCulture : coculture_configuration CoCulture --> "0..1" CocultureConfigurationEnum : coculture_configuration click CocultureConfigurationEnum href "../CocultureConfigurationEnum/" CoCulture : complexity_level CoCulture --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" CoCulture : culture_conditions CoCulture : description CoCulture : id CoCulture : interaction_mechanisms CoCulture : models CoCulture --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" CoCulture : name CoCulture : references CoCulture --> "*" Reference : references click Reference href "../Reference/" CoCulture : spatial_context CoCulture : type
## Inheritance * [NamedThing](NamedThing.md) * [ModelSystem](ModelSystem.md) * [NAMModel](NAMModel.md) * [CellularSystem](CellularSystem.md) * **CoCulture** ## Slots | Name | Cardinality and Range | Description | Inheritance | | --- | --- | --- | --- | | [coculture_configuration](coculture_configuration.md) | 0..1
[CocultureConfigurationEnum](CocultureConfigurationEnum.md) | Configuration of co-culture (direct contact, transwell, conditioned media) | direct | | [cell_ratios](cell_ratios.md) | *
[CellRatio](CellRatio.md) | Ratios of different cell types in the co-culture | direct | | [interaction_mechanisms](interaction_mechanisms.md) | *
[String](String.md) | Mechanisms of cell-cell interaction (paracrine, direct contact, mechanical) | direct | | [cell_types](cell_types.md) | *
[Cell](Cell.md) | Cell types present in the cellular system | [CellularSystem](CellularSystem.md) | | [cell_source](cell_source.md) | 0..1
[String](String.md) | Source of cells (e | [CellularSystem](CellularSystem.md) | | [culture_conditions](culture_conditions.md) | 0..1
[String](String.md) | Standard culture conditions and media used | [CellularSystem](CellularSystem.md) | | [biological_organization_level](biological_organization_level.md) | 0..1
[BiologicalOrganizationLevelEnum](BiologicalOrganizationLevelEnum.md) | The level of biological organization represented by the model | [NAMModel](NAMModel.md) | | [spatial_context](spatial_context.md) | 0..1
[String](String.md) | Description of spatial organization and context captured by the model | [NAMModel](NAMModel.md) | | [complexity_level](complexity_level.md) | 0..1
[ComplexityLevelEnum](ComplexityLevelEnum.md) | Level of biological complexity represented (subcellular, cellular, tissue, or... | [NAMModel](NAMModel.md) | | [references](references.md) | *
[Reference](Reference.md) | Literature references that describe, validate, or support this model | [NAMModel](NAMModel.md) | | [models](models.md) | *
[ModelsRelationship](ModelsRelationship.md) | | [ModelSystem](ModelSystem.md) | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | A unique identifier for a thing | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | A human-readable name for a thing | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | A human-readable description for a thing | [NamedThing](NamedThing.md) | | [type](type.md) | 0..1
[String](String.md) | | [NamedThing](NamedThing.md) | ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/monarch-initiative/namo ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | namo:CoCulture | | native | namo:CoCulture | ## LinkML Source ### Direct 
name: CoCulture
description: Co-culture systems combining multiple cell types to mimic  microenvironments
  and cell-cell interactions.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: CellularSystem
attributes:
  coculture_configuration:
    name: coculture_configuration
    description: Configuration of co-culture (direct contact, transwell, conditioned
      media)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CoCulture
    range: CocultureConfigurationEnum
  cell_ratios:
    name: cell_ratios
    description: Ratios of different cell types in the co-culture
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CoCulture
    range: CellRatio
    multivalued: true
    inlined_as_list: true
  interaction_mechanisms:
    name: interaction_mechanisms
    description: Mechanisms of cell-cell interaction (paracrine, direct contact, mechanical)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - CoCulture
    multivalued: true
### Induced 
name: CoCulture
description: Co-culture systems combining multiple cell types to mimic  microenvironments
  and cell-cell interactions.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: CellularSystem
attributes:
  coculture_configuration:
    name: coculture_configuration
    description: Configuration of co-culture (direct contact, transwell, conditioned
      media)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - CoCulture
    range: CocultureConfigurationEnum
  cell_ratios:
    name: cell_ratios
    description: Ratios of different cell types in the co-culture
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - CoCulture
    range: CellRatio
    multivalued: true
    inlined: true
    inlined_as_list: true
  interaction_mechanisms:
    name: interaction_mechanisms
    description: Mechanisms of cell-cell interaction (paracrine, direct contact, mechanical)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - CoCulture
    range: string
    multivalued: true
  cell_types:
    name: cell_types
    description: Cell types present in the cellular system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: Cell
    bindings:
    - range: CellTypeEnum
      obligation_level: REQUIRED
      binds_value_of: id
    multivalued: true
    inlined: true
    inlined_as_list: true
  cell_source:
    name: cell_source
    description: Source of cells (e.g., primary, iPSC-derived, immortalized cell lines)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: string
  culture_conditions:
    name: culture_conditions
    description: Standard culture conditions and media used
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - CellularSystem
    range: string
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: CoCulture
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    owner: CoCulture
    domain_of:
    - NamedThing
    - Reference
    - BiolinkEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    owner: CoCulture
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    owner: CoCulture
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    owner: CoCulture
    domain_of:
    - NamedThing
    range: string