Class: DrugProperties

Physicochemical and pharmacological properties of a drug in PBPK models.

classDiagram class DrugProperties click DrugProperties href "../DrugProperties/" DrugProperties : clearance DrugProperties : logp DrugProperties : molecular_weight DrugProperties : pka DrugProperties : protein_binding

Slots

Name	Cardinality and Range	Description	Inheritance
molecular_weight	0..1 Float	Molecular weight (g/mol)	direct
logp	0..1 Float	Lipophilicity (log P)	direct
pka	0..1 Float	Acid dissociation constant	direct
protein_binding	0..1 Float	Fraction bound to plasma proteins (0	direct
clearance	0..1 Float	Total body clearance (L/h)	direct

Usages

used by	used in	type	used
PBPKModel	drug_properties	range	DrugProperties

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/monarch-initiative/namo

Mappings

Mapping Type	Mapped Value
self	namo:DrugProperties
native	namo:DrugProperties

LinkML Source

Direct

name: DrugProperties
description: Physicochemical and pharmacological properties of a drug in PBPK models.
from_schema: https://w3id.org/monarch-initiative/namo
attributes:
  molecular_weight:
    name: molecular_weight
    description: Molecular weight (g/mol)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - DrugProperties
    range: float
  logp:
    name: logp
    description: Lipophilicity (log P)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - DrugProperties
    range: float
  pka:
    name: pka
    description: Acid dissociation constant
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - DrugProperties
    range: float
  protein_binding:
    name: protein_binding
    description: Fraction bound to plasma proteins (0.0-1.0)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - DrugProperties
    range: float
  clearance:
    name: clearance
    description: Total body clearance (L/h)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - DrugProperties
    range: float

Induced

name: DrugProperties
description: Physicochemical and pharmacological properties of a drug in PBPK models.
from_schema: https://w3id.org/monarch-initiative/namo
attributes:
  molecular_weight:
    name: molecular_weight
    description: Molecular weight (g/mol)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: molecular_weight
    owner: DrugProperties
    domain_of:
    - DrugProperties
    range: float
  logp:
    name: logp
    description: Lipophilicity (log P)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: logp
    owner: DrugProperties
    domain_of:
    - DrugProperties
    range: float
  pka:
    name: pka
    description: Acid dissociation constant
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: pka
    owner: DrugProperties
    domain_of:
    - DrugProperties
    range: float
  protein_binding:
    name: protein_binding
    description: Fraction bound to plasma proteins (0.0-1.0)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: protein_binding
    owner: DrugProperties
    domain_of:
    - DrugProperties
    range: float
  clearance:
    name: clearance
    description: Total body clearance (L/h)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: clearance
    owner: DrugProperties
    domain_of:
    - DrugProperties
    range: float