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Class: MicrophysiologicalSystem

Organ-/tissue-on-chip systems that integrate microfluidics, biomaterials, and living cells to replicate tissue-level physiology and dynamics.

  • NOTE: this is an abstract class and should not be instantiated directly

URI: namo:MicrophysiologicalSystem

classDiagram class MicrophysiologicalSystem click MicrophysiologicalSystem href "../MicrophysiologicalSystem/" NAMModel <|-- MicrophysiologicalSystem click NAMModel href "../NAMModel/" MicrophysiologicalSystem <|-- OrganOnChip click OrganOnChip href "../OrganOnChip/" MicrophysiologicalSystem <|-- TissueOnChip click TissueOnChip href "../TissueOnChip/" MicrophysiologicalSystem : biological_organization_level MicrophysiologicalSystem --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" MicrophysiologicalSystem : complexity_level MicrophysiologicalSystem --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" MicrophysiologicalSystem : description MicrophysiologicalSystem : id MicrophysiologicalSystem : mechanical_forces MicrophysiologicalSystem --> "0..1" MechanicalStimulation : mechanical_forces click MechanicalStimulation href "../MechanicalStimulation/" MicrophysiologicalSystem : microfluidic_design MicrophysiologicalSystem --> "0..1" MicrofluidicDesign : microfluidic_design click MicrofluidicDesign href "../MicrofluidicDesign/" MicrophysiologicalSystem : models MicrophysiologicalSystem --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" MicrophysiologicalSystem : name MicrophysiologicalSystem : perfusion_system MicrophysiologicalSystem : references MicrophysiologicalSystem --> "*" Reference : references click Reference href "../Reference/" MicrophysiologicalSystem : sensor_integration MicrophysiologicalSystem --> "*" IntegratedSensorEnum : sensor_integration click IntegratedSensorEnum href "../IntegratedSensorEnum/" MicrophysiologicalSystem : spatial_context MicrophysiologicalSystem : type

Inheritance

Slots

Name Cardinality and Range Description Inheritance
microfluidic_design 0..1
MicrofluidicDesign		 Detailed design specifications of the microfluidic device direct
mechanical_forces 0..1
MechanicalStimulation		 Mechanical forces applied to the model system direct
perfusion_system 0..1
String		 Description of perfusion and flow systems direct
sensor_integration *
IntegratedSensorEnum		 Sensors integrated for real-time monitoring direct
biological_organization_level 0..1
BiologicalOrganizationLevelEnum		 The level of biological organization represented by the model NAMModel
spatial_context 0..1
String		 Description of spatial organization and context captured by the model NAMModel
complexity_level 0..1
ComplexityLevelEnum		 Level of biological complexity represented (subcellular, cellular, tissue, or... NAMModel
references *
Reference		 Literature references that describe, validate, or support this model NAMModel
models *
ModelsRelationship		 ModelSystem
id 1
Uriorcurie		 A unique identifier for a thing NamedThing
name 0..1
String		 A human-readable name for a thing NamedThing
description 0..1
String		 A human-readable description for a thing NamedThing
type 0..1
String		 NamedThing

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/namo

Mappings

Mapping Type Mapped Value
self namo:MicrophysiologicalSystem
native namo:MicrophysiologicalSystem

LinkML Source

Direct

name: MicrophysiologicalSystem
description: Organ-/tissue-on-chip systems that integrate microfluidics, biomaterials,  and
  living cells to replicate tissue-level physiology and dynamics.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: NAMModel
abstract: true
attributes:
  microfluidic_design:
    name: microfluidic_design
    description: Detailed design specifications of the microfluidic device
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
    range: MicrofluidicDesign
    inlined: true
  mechanical_forces:
    name: mechanical_forces
    description: Mechanical forces applied to the model system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
    range: MechanicalStimulation
    inlined: true
  perfusion_system:
    name: perfusion_system
    description: Description of perfusion and flow systems
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
  sensor_integration:
    name: sensor_integration
    description: Sensors integrated for real-time monitoring
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
    range: IntegratedSensorEnum
    multivalued: true

Induced

name: MicrophysiologicalSystem
description: Organ-/tissue-on-chip systems that integrate microfluidics, biomaterials,  and
  living cells to replicate tissue-level physiology and dynamics.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: NAMModel
abstract: true
attributes:
  microfluidic_design:
    name: microfluidic_design
    description: Detailed design specifications of the microfluidic device
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: microfluidic_design
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: MicrofluidicDesign
    inlined: true
  mechanical_forces:
    name: mechanical_forces
    description: Mechanical forces applied to the model system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: mechanical_forces
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: MechanicalStimulation
    inlined: true
  perfusion_system:
    name: perfusion_system
    description: Description of perfusion and flow systems
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: perfusion_system
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: string
  sensor_integration:
    name: sensor_integration
    description: Sensors integrated for real-time monitoring
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: sensor_integration
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: IntegratedSensorEnum
    multivalued: true
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: biological_organization_level
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: spatial_context
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: complexity_level
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: references
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: models
    owner: MicrophysiologicalSystem
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    alias: id
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    - Reference
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    alias: type
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    range: string