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Class: MicrophysiologicalSystem

Organ-/tissue-on-chip systems that integrate microfluidics, biomaterials, and living cells to replicate tissue-level physiology and dynamics. Conforms to ISO 22916:2022 interoperability requirements for dimensions, connections, and device classification.

* __NOTE__: this is an abstract class and should not be instantiated directly URI: [namo:MicrophysiologicalSystem](https://w3id.org/monarch-initiative/namo/MicrophysiologicalSystem)
classDiagram class MicrophysiologicalSystem click MicrophysiologicalSystem href "../MicrophysiologicalSystem/" NAMModel <|-- MicrophysiologicalSystem click NAMModel href "../NAMModel/" MicrophysiologicalSystem <|-- OrganOnChip click OrganOnChip href "../OrganOnChip/" MicrophysiologicalSystem <|-- TissueOnChip click TissueOnChip href "../TissueOnChip/" MicrophysiologicalSystem : biological_organization_level MicrophysiologicalSystem --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" MicrophysiologicalSystem : complexity_level MicrophysiologicalSystem --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" MicrophysiologicalSystem : description MicrophysiologicalSystem : id MicrophysiologicalSystem : mechanical_forces MicrophysiologicalSystem --> "0..1" MechanicalStimulation : mechanical_forces click MechanicalStimulation href "../MechanicalStimulation/" MicrophysiologicalSystem : microfluidic_design MicrophysiologicalSystem --> "0..1" MicrofluidicDesign : microfluidic_design click MicrofluidicDesign href "../MicrofluidicDesign/" MicrophysiologicalSystem : models MicrophysiologicalSystem --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" MicrophysiologicalSystem : name MicrophysiologicalSystem : perfusion_system MicrophysiologicalSystem : references MicrophysiologicalSystem --> "*" Reference : references click Reference href "../Reference/" MicrophysiologicalSystem : sensor_integration MicrophysiologicalSystem --> "*" IntegratedSensorEnum : sensor_integration click IntegratedSensorEnum href "../IntegratedSensorEnum/" MicrophysiologicalSystem : spatial_context MicrophysiologicalSystem : type
## Inheritance * [NamedThing](NamedThing.md) * [ModelSystem](ModelSystem.md) * [NAMModel](NAMModel.md) * **MicrophysiologicalSystem** * [OrganOnChip](OrganOnChip.md) * [TissueOnChip](TissueOnChip.md) ## Slots | Name | Cardinality and Range | Description | Inheritance | | --- | --- | --- | --- | | [microfluidic_design](microfluidic_design.md) | 0..1
[MicrofluidicDesign](MicrofluidicDesign.md) | Detailed design specifications of the microfluidic device | direct | | [mechanical_forces](mechanical_forces.md) | 0..1
[MechanicalStimulation](MechanicalStimulation.md) | Mechanical forces applied to the model system | direct | | [perfusion_system](perfusion_system.md) | 0..1
[String](String.md) | Description of perfusion and flow systems | direct | | [sensor_integration](sensor_integration.md) | *
[IntegratedSensorEnum](IntegratedSensorEnum.md) | Sensors integrated for real-time monitoring | direct | | [biological_organization_level](biological_organization_level.md) | 0..1
[BiologicalOrganizationLevelEnum](BiologicalOrganizationLevelEnum.md) | The level of biological organization represented by the model | [NAMModel](NAMModel.md) | | [spatial_context](spatial_context.md) | 0..1
[String](String.md) | Description of spatial organization and context captured by the model | [NAMModel](NAMModel.md) | | [complexity_level](complexity_level.md) | 0..1
[ComplexityLevelEnum](ComplexityLevelEnum.md) | Level of biological complexity represented (subcellular, cellular, tissue, or... | [NAMModel](NAMModel.md) | | [references](references.md) | *
[Reference](Reference.md) | Literature references that describe, validate, or support this model | [NAMModel](NAMModel.md) | | [models](models.md) | *
[ModelsRelationship](ModelsRelationship.md) | | [ModelSystem](ModelSystem.md) | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | A unique identifier for a thing | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | A human-readable name for a thing | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | A human-readable description for a thing | [NamedThing](NamedThing.md) | | [type](type.md) | 0..1
[String](String.md) | | [NamedThing](NamedThing.md) | ## See Also * [https://www.iso.org/standard/74157.html](https://www.iso.org/standard/74157.html) ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/monarch-initiative/namo ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | namo:MicrophysiologicalSystem | | native | namo:MicrophysiologicalSystem | | exact | ISO22916:microfluidic_device | ## LinkML Source ### Direct 
name: MicrophysiologicalSystem
description: Organ-/tissue-on-chip systems that integrate microfluidics, biomaterials,
  and living cells to replicate tissue-level physiology and dynamics. Conforms to
  ISO 22916:2022 interoperability requirements for dimensions, connections, and device
  classification.
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/74157.html
exact_mappings:
- ISO22916:microfluidic_device
is_a: NAMModel
abstract: true
attributes:
  microfluidic_design:
    name: microfluidic_design
    description: Detailed design specifications of the microfluidic device
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
    range: MicrofluidicDesign
    inlined: true
  mechanical_forces:
    name: mechanical_forces
    description: Mechanical forces applied to the model system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
    range: MechanicalStimulation
    inlined: true
  perfusion_system:
    name: perfusion_system
    description: Description of perfusion and flow systems
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
  sensor_integration:
    name: sensor_integration
    description: Sensors integrated for real-time monitoring
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MicrophysiologicalSystem
    range: IntegratedSensorEnum
    multivalued: true
### Induced 
name: MicrophysiologicalSystem
description: Organ-/tissue-on-chip systems that integrate microfluidics, biomaterials,
  and living cells to replicate tissue-level physiology and dynamics. Conforms to
  ISO 22916:2022 interoperability requirements for dimensions, connections, and device
  classification.
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/74157.html
exact_mappings:
- ISO22916:microfluidic_device
is_a: NAMModel
abstract: true
attributes:
  microfluidic_design:
    name: microfluidic_design
    description: Detailed design specifications of the microfluidic device
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: MicrofluidicDesign
    inlined: true
  mechanical_forces:
    name: mechanical_forces
    description: Mechanical forces applied to the model system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: MechanicalStimulation
    inlined: true
  perfusion_system:
    name: perfusion_system
    description: Description of perfusion and flow systems
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: string
  sensor_integration:
    name: sensor_integration
    description: Sensors integrated for real-time monitoring
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - MicrophysiologicalSystem
    range: IntegratedSensorEnum
    multivalued: true
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MicrophysiologicalSystem
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    - Reference
    - BiolinkEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    owner: MicrophysiologicalSystem
    domain_of:
    - NamedThing
    range: string