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Class: MolecularSimilarity

Detailed assessment of molecular-level concordance between model and biological systems.

URI: [namo:MolecularSimilarity](https://w3id.org/monarch-initiative/namo/MolecularSimilarity)
classDiagram class MolecularSimilarity click MolecularSimilarity href "../MolecularSimilarity/" NamedThing <|-- MolecularSimilarity click NamedThing href "../NamedThing/" MolecularSimilarity : conserved_genes MolecularSimilarity --> "*" Gene : conserved_genes click Gene href "../Gene/" MolecularSimilarity : correlation_coefficient MolecularSimilarity : data_source MolecularSimilarity : description MolecularSimilarity : differentially_expressed_genes MolecularSimilarity --> "*" Gene : differentially_expressed_genes click Gene href "../Gene/" MolecularSimilarity : id MolecularSimilarity : methodology MolecularSimilarity : name MolecularSimilarity : similarity_score MolecularSimilarity : statistical_significance MolecularSimilarity --> "0..1" StatisticalSignificance : statistical_significance click StatisticalSignificance href "../StatisticalSignificance/" MolecularSimilarity : type
## Inheritance * [NamedThing](NamedThing.md) * **MolecularSimilarity** ## Slots | Name | Cardinality and Range | Description | Inheritance | | --- | --- | --- | --- | | [similarity_score](similarity_score.md) | 0..1
[Float](Float.md) | Quantitative similarity score (0 | direct | | [correlation_coefficient](correlation_coefficient.md) | 0..1
[Float](Float.md) | Pearson correlation coefficient for expression profiles | direct | | [differentially_expressed_genes](differentially_expressed_genes.md) | *
[Gene](Gene.md) | List of genes that are differentially expressed in the model system | direct | | [conserved_genes](conserved_genes.md) | *
[Gene](Gene.md) | List of genes with conserved expression patterns between model and target | direct | | [methodology](methodology.md) | 0..1
[String](String.md) | Description of experimental methods used for molecular comparison | direct | | [data_source](data_source.md) | 0..1
[String](String.md) | Source of molecular data (e | direct | | [statistical_significance](statistical_significance.md) | 0..1
[StatisticalSignificance](StatisticalSignificance.md) | Statistical measures of significance for the molecular similarity | direct | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | A unique identifier for a thing | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | A human-readable name for a thing | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | A human-readable description for a thing | [NamedThing](NamedThing.md) | | [type](type.md) | 0..1
[String](String.md) | | [NamedThing](NamedThing.md) | ## Usages | used by | used in | type | used | | --- | --- | --- | --- | | [StructuredConcordanceResult](StructuredConcordanceResult.md) | [molecular_similarity](molecular_similarity.md) | range | [MolecularSimilarity](MolecularSimilarity.md) | ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/monarch-initiative/namo ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | namo:MolecularSimilarity | | native | namo:MolecularSimilarity | ## LinkML Source ### Direct 
name: MolecularSimilarity
description: Detailed assessment of molecular-level concordance between model and
  biological systems.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: NamedThing
attributes:
  similarity_score:
    name: similarity_score
    description: Quantitative similarity score (0.0-1.0) based on molecular profiles.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MolecularSimilarity
    range: float
  correlation_coefficient:
    name: correlation_coefficient
    description: Pearson correlation coefficient for expression profiles.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MolecularSimilarity
    - DoseResponseSimilarity
    range: float
  differentially_expressed_genes:
    name: differentially_expressed_genes
    description: List of genes that are differentially expressed in the model system.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MolecularSimilarity
    range: Gene
    multivalued: true
    inlined_as_list: true
  conserved_genes:
    name: conserved_genes
    description: List of genes with conserved expression patterns between model and
      target.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MolecularSimilarity
    range: Gene
    multivalued: true
    inlined_as_list: true
  methodology:
    name: methodology
    description: Description of experimental methods used for molecular comparison.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MolecularSimilarity
    - FunctionalAssay
  data_source:
    name: data_source
    description: Source of molecular data (e.g., RNA-seq, proteomics, metabolomics).
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MolecularSimilarity
  statistical_significance:
    name: statistical_significance
    description: Statistical measures of significance for the molecular similarity.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - MolecularSimilarity
    range: StatisticalSignificance
    inlined: true
### Induced 
name: MolecularSimilarity
description: Detailed assessment of molecular-level concordance between model and
  biological systems.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: NamedThing
attributes:
  similarity_score:
    name: similarity_score
    description: Quantitative similarity score (0.0-1.0) based on molecular profiles.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MolecularSimilarity
    domain_of:
    - MolecularSimilarity
    range: float
  correlation_coefficient:
    name: correlation_coefficient
    description: Pearson correlation coefficient for expression profiles.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MolecularSimilarity
    domain_of:
    - MolecularSimilarity
    - DoseResponseSimilarity
    range: float
  differentially_expressed_genes:
    name: differentially_expressed_genes
    description: List of genes that are differentially expressed in the model system.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MolecularSimilarity
    domain_of:
    - MolecularSimilarity
    range: Gene
    multivalued: true
    inlined: true
    inlined_as_list: true
  conserved_genes:
    name: conserved_genes
    description: List of genes with conserved expression patterns between model and
      target.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MolecularSimilarity
    domain_of:
    - MolecularSimilarity
    range: Gene
    multivalued: true
    inlined: true
    inlined_as_list: true
  methodology:
    name: methodology
    description: Description of experimental methods used for molecular comparison.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MolecularSimilarity
    domain_of:
    - MolecularSimilarity
    - FunctionalAssay
    range: string
  data_source:
    name: data_source
    description: Source of molecular data (e.g., RNA-seq, proteomics, metabolomics).
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MolecularSimilarity
    domain_of:
    - MolecularSimilarity
    range: string
  statistical_significance:
    name: statistical_significance
    description: Statistical measures of significance for the molecular similarity.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: MolecularSimilarity
    domain_of:
    - MolecularSimilarity
    range: StatisticalSignificance
    inlined: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    owner: MolecularSimilarity
    domain_of:
    - NamedThing
    - Reference
    - BiolinkEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    owner: MolecularSimilarity
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    owner: MolecularSimilarity
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    owner: MolecularSimilarity
    domain_of:
    - NamedThing
    range: string