Class: OrganOnChip

A model system that simulates the physiological functions of an organ using a microfluidic device. Examples: Airway-on-chip, ... Aligned with ISO 10991:2023 microfluidics terminology.

URI: namo:OrganOnChip

classDiagram class OrganOnChip click OrganOnChip href "../OrganOnChip/" MicrophysiologicalSystem <|-- OrganOnChip click MicrophysiologicalSystem href "../MicrophysiologicalSystem/" OrganOnChip : biological_organization_level OrganOnChip --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" OrganOnChip : cell_source OrganOnChip : cell_types OrganOnChip --> "*" Term : cell_types click Term href "../Term/" OrganOnChip : complexity_level OrganOnChip --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" OrganOnChip : description OrganOnChip : id OrganOnChip : mechanical_forces OrganOnChip --> "0..1" MechanicalStimulation : mechanical_forces click MechanicalStimulation href "../MechanicalStimulation/" OrganOnChip : microfluidic_design OrganOnChip --> "0..1" MicrofluidicDesign : microfluidic_design click MicrofluidicDesign href "../MicrofluidicDesign/" OrganOnChip : models OrganOnChip --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" OrganOnChip : name OrganOnChip : organ_modeled OrganOnChip --> "0..1" Term : organ_modeled click Term href "../Term/" OrganOnChip : perfusion_system OrganOnChip : references OrganOnChip --> "*" Reference : references click Reference href "../Reference/" OrganOnChip : sensor_integration OrganOnChip --> "*" IntegratedSensorEnum : sensor_integration click IntegratedSensorEnum href "../IntegratedSensorEnum/" OrganOnChip : spatial_context OrganOnChip : type

Inheritance

NamedThing
- ModelSystem
  - NAMModel
    - MicrophysiologicalSystem
      - OrganOnChip

Slots

Name	Cardinality and Range	Description	Inheritance
organ_modeled	0..1 Term	The organ or anatomical structure being modeled (e	direct
cell_types	* Term	Cell types present in the organ-on-chip model	direct
cell_source	0..1 String	Source of cells (e	direct
microfluidic_design	0..1 MicrofluidicDesign	Detailed design specifications of the microfluidic device	MicrophysiologicalSystem
mechanical_forces	0..1 MechanicalStimulation	Mechanical forces applied to the model system	MicrophysiologicalSystem
perfusion_system	0..1 String	Description of perfusion and flow systems	MicrophysiologicalSystem
sensor_integration	* IntegratedSensorEnum	Sensors integrated for real-time monitoring	MicrophysiologicalSystem
biological_organization_level	0..1 BiologicalOrganizationLevelEnum	The level of biological organization represented by the model	NAMModel
spatial_context	0..1 String	Description of spatial organization and context captured by the model	NAMModel
complexity_level	0..1 ComplexityLevelEnum	Level of biological complexity represented (subcellular, cellular, tissue, or...	NAMModel
references	* Reference	Literature references that describe, validate, or support this model	NAMModel
models	* ModelsRelationship		ModelSystem
id	1 Uriorcurie	A unique identifier for a thing	NamedThing
name	0..1 String	A human-readable name for a thing	NamedThing
description	0..1 String	A human-readable description for a thing	NamedThing
type	0..1 String		NamedThing

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/monarch-initiative/namo

Mappings

Mapping Type	Mapped Value
self	namo:OrganOnChip
native	namo:OrganOnChip
exact	ISO10991:organ_on_chip

LinkML Source

Direct

name: OrganOnChip
description: 'A model system that simulates the physiological functions of an organ
  using a microfluidic device. Examples: Airway-on-chip, ... Aligned with ISO 10991:2023
  microfluidics terminology.'
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/82146.html
exact_mappings:
- ISO10991:organ_on_chip
is_a: MicrophysiologicalSystem
attributes:
  organ_modeled:
    name: organ_modeled
    description: The organ or anatomical structure being modeled (e.g., lung, airway,
      alveolus)
    from_schema: https://w3id.org/monarch-initiative/namo
    domain_of:
    - Organoid
    - OrganOnChip
    range: Term
    bindings:
    - range: OrganEnum
      obligation_level: REQUIRED
      binds_value_of: id
    inlined: true
  cell_types:
    name: cell_types
    description: Cell types present in the organ-on-chip model
    from_schema: https://w3id.org/monarch-initiative/namo
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: Term
    bindings:
    - range: CellTypeEnum
      obligation_level: REQUIRED
      binds_value_of: id
    multivalued: true
    inlined: true
    inlined_as_list: true
  cell_source:
    name: cell_source
    description: Source of cells (e.g., primary human cells, iPSC-derived, cell line,
      patient-derived)
    from_schema: https://w3id.org/monarch-initiative/namo
    domain_of:
    - CellularSystem
    - OrganOnChip

Induced

name: OrganOnChip
description: 'A model system that simulates the physiological functions of an organ
  using a microfluidic device. Examples: Airway-on-chip, ... Aligned with ISO 10991:2023
  microfluidics terminology.'
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/82146.html
exact_mappings:
- ISO10991:organ_on_chip
is_a: MicrophysiologicalSystem
attributes:
  organ_modeled:
    name: organ_modeled
    description: The organ or anatomical structure being modeled (e.g., lung, airway,
      alveolus)
    from_schema: https://w3id.org/monarch-initiative/namo
    alias: organ_modeled
    owner: OrganOnChip
    domain_of:
    - Organoid
    - OrganOnChip
    range: Term
    bindings:
    - range: OrganEnum
      obligation_level: REQUIRED
      binds_value_of: id
    inlined: true
  cell_types:
    name: cell_types
    description: Cell types present in the organ-on-chip model
    from_schema: https://w3id.org/monarch-initiative/namo
    alias: cell_types
    owner: OrganOnChip
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: Term
    bindings:
    - range: CellTypeEnum
      obligation_level: REQUIRED
      binds_value_of: id
    multivalued: true
    inlined: true
    inlined_as_list: true
  cell_source:
    name: cell_source
    description: Source of cells (e.g., primary human cells, iPSC-derived, cell line,
      patient-derived)
    from_schema: https://w3id.org/monarch-initiative/namo
    alias: cell_source
    owner: OrganOnChip
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: string
  microfluidic_design:
    name: microfluidic_design
    description: Detailed design specifications of the microfluidic device
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: microfluidic_design
    owner: OrganOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: MicrofluidicDesign
    inlined: true
  mechanical_forces:
    name: mechanical_forces
    description: Mechanical forces applied to the model system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: mechanical_forces
    owner: OrganOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: MechanicalStimulation
    inlined: true
  perfusion_system:
    name: perfusion_system
    description: Description of perfusion and flow systems
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: perfusion_system
    owner: OrganOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: string
  sensor_integration:
    name: sensor_integration
    description: Sensors integrated for real-time monitoring
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: sensor_integration
    owner: OrganOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: IntegratedSensorEnum
    multivalued: true
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: biological_organization_level
    owner: OrganOnChip
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: spatial_context
    owner: OrganOnChip
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: complexity_level
    owner: OrganOnChip
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: references
    owner: OrganOnChip
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: models
    owner: OrganOnChip
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    alias: id
    owner: OrganOnChip
    domain_of:
    - NamedThing
    - Reference
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: OrganOnChip
    domain_of:
    - NamedThing
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: OrganOnChip
    domain_of:
    - NamedThing
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    alias: type
    owner: OrganOnChip
    domain_of:
    - NamedThing
    range: string