Class: OrganOnChip
A model system that simulates the physiological functions of an organ using a microfluidic device. Examples: Airway-on-chip, ... Aligned with ISO 10991:2023 microfluidics terminology.
URI: [namo:OrganOnChip](https://w3id.org/monarch-initiative/namo/OrganOnChip)
[GrossAnatomicalStructure](GrossAnatomicalStructure.md) | The organ or anatomical structure being modeled (e | direct | | [cell_types](cell_types.md) | *
[Cell](Cell.md) | Cell types present in the organ-on-chip model | direct | | [cell_source](cell_source.md) | 0..1
[String](String.md) | Source of cells (e | direct | | [microfluidic_design](microfluidic_design.md) | 0..1
[MicrofluidicDesign](MicrofluidicDesign.md) | Detailed design specifications of the microfluidic device | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [mechanical_forces](mechanical_forces.md) | 0..1
[MechanicalStimulation](MechanicalStimulation.md) | Mechanical forces applied to the model system | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [perfusion_system](perfusion_system.md) | 0..1
[String](String.md) | Description of perfusion and flow systems | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [sensor_integration](sensor_integration.md) | *
[IntegratedSensorEnum](IntegratedSensorEnum.md) | Sensors integrated for real-time monitoring | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [biological_organization_level](biological_organization_level.md) | 0..1
[BiologicalOrganizationLevelEnum](BiologicalOrganizationLevelEnum.md) | The level of biological organization represented by the model | [NAMModel](NAMModel.md) | | [spatial_context](spatial_context.md) | 0..1
[String](String.md) | Description of spatial organization and context captured by the model | [NAMModel](NAMModel.md) | | [complexity_level](complexity_level.md) | 0..1
[ComplexityLevelEnum](ComplexityLevelEnum.md) | Level of biological complexity represented (subcellular, cellular, tissue, or... | [NAMModel](NAMModel.md) | | [references](references.md) | *
[Reference](Reference.md) | Literature references that describe, validate, or support this model | [NAMModel](NAMModel.md) | | [models](models.md) | *
[ModelsRelationship](ModelsRelationship.md) | | [ModelSystem](ModelSystem.md) | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | A unique identifier for a thing | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | A human-readable name for a thing | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | A human-readable description for a thing | [NamedThing](NamedThing.md) | | [type](type.md) | 0..1
[String](String.md) | | [NamedThing](NamedThing.md) | ## See Also * [https://www.iso.org/standard/82146.html](https://www.iso.org/standard/82146.html) ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/monarch-initiative/namo ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | namo:OrganOnChip | | native | namo:OrganOnChip | | exact | ISO10991:organ_on_chip | ## LinkML Source ### Direct
### Induced
classDiagram
class OrganOnChip
click OrganOnChip href "../OrganOnChip/"
MicrophysiologicalSystem <|-- OrganOnChip
click MicrophysiologicalSystem href "../MicrophysiologicalSystem/"
OrganOnChip : biological_organization_level
OrganOnChip --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level
click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/"
OrganOnChip : cell_source
OrganOnChip : cell_types
OrganOnChip --> "*" Cell : cell_types
click Cell href "../Cell/"
OrganOnChip : complexity_level
OrganOnChip --> "0..1" ComplexityLevelEnum : complexity_level
click ComplexityLevelEnum href "../ComplexityLevelEnum/"
OrganOnChip : description
OrganOnChip : id
OrganOnChip : mechanical_forces
OrganOnChip --> "0..1" MechanicalStimulation : mechanical_forces
click MechanicalStimulation href "../MechanicalStimulation/"
OrganOnChip : microfluidic_design
OrganOnChip --> "0..1" MicrofluidicDesign : microfluidic_design
click MicrofluidicDesign href "../MicrofluidicDesign/"
OrganOnChip : models
OrganOnChip --> "*" ModelsRelationship : models
click ModelsRelationship href "../ModelsRelationship/"
OrganOnChip : name
OrganOnChip : organ_modeled
OrganOnChip --> "0..1" GrossAnatomicalStructure : organ_modeled
click GrossAnatomicalStructure href "../GrossAnatomicalStructure/"
OrganOnChip : perfusion_system
OrganOnChip : references
OrganOnChip --> "*" Reference : references
click Reference href "../Reference/"
OrganOnChip : sensor_integration
OrganOnChip --> "*" IntegratedSensorEnum : sensor_integration
click IntegratedSensorEnum href "../IntegratedSensorEnum/"
OrganOnChip : spatial_context
OrganOnChip : type
## Inheritance
* [NamedThing](NamedThing.md)
* [ModelSystem](ModelSystem.md)
* [NAMModel](NAMModel.md)
* [MicrophysiologicalSystem](MicrophysiologicalSystem.md)
* **OrganOnChip**
## Slots
| Name | Cardinality and Range | Description | Inheritance |
| --- | --- | --- | --- |
| [organ_modeled](organ_modeled.md) | 0..1 [GrossAnatomicalStructure](GrossAnatomicalStructure.md) | The organ or anatomical structure being modeled (e | direct | | [cell_types](cell_types.md) | *
[Cell](Cell.md) | Cell types present in the organ-on-chip model | direct | | [cell_source](cell_source.md) | 0..1
[String](String.md) | Source of cells (e | direct | | [microfluidic_design](microfluidic_design.md) | 0..1
[MicrofluidicDesign](MicrofluidicDesign.md) | Detailed design specifications of the microfluidic device | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [mechanical_forces](mechanical_forces.md) | 0..1
[MechanicalStimulation](MechanicalStimulation.md) | Mechanical forces applied to the model system | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [perfusion_system](perfusion_system.md) | 0..1
[String](String.md) | Description of perfusion and flow systems | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [sensor_integration](sensor_integration.md) | *
[IntegratedSensorEnum](IntegratedSensorEnum.md) | Sensors integrated for real-time monitoring | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [biological_organization_level](biological_organization_level.md) | 0..1
[BiologicalOrganizationLevelEnum](BiologicalOrganizationLevelEnum.md) | The level of biological organization represented by the model | [NAMModel](NAMModel.md) | | [spatial_context](spatial_context.md) | 0..1
[String](String.md) | Description of spatial organization and context captured by the model | [NAMModel](NAMModel.md) | | [complexity_level](complexity_level.md) | 0..1
[ComplexityLevelEnum](ComplexityLevelEnum.md) | Level of biological complexity represented (subcellular, cellular, tissue, or... | [NAMModel](NAMModel.md) | | [references](references.md) | *
[Reference](Reference.md) | Literature references that describe, validate, or support this model | [NAMModel](NAMModel.md) | | [models](models.md) | *
[ModelsRelationship](ModelsRelationship.md) | | [ModelSystem](ModelSystem.md) | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | A unique identifier for a thing | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | A human-readable name for a thing | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | A human-readable description for a thing | [NamedThing](NamedThing.md) | | [type](type.md) | 0..1
[String](String.md) | | [NamedThing](NamedThing.md) | ## See Also * [https://www.iso.org/standard/82146.html](https://www.iso.org/standard/82146.html) ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/monarch-initiative/namo ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | namo:OrganOnChip | | native | namo:OrganOnChip | | exact | ISO10991:organ_on_chip | ## LinkML Source ### Direct
name: OrganOnChip
description: 'A model system that simulates the physiological functions of an organ
using a microfluidic device. Examples: Airway-on-chip, ... Aligned with ISO 10991:2023
microfluidics terminology.'
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/82146.html
exact_mappings:
- ISO10991:organ_on_chip
is_a: MicrophysiologicalSystem
attributes:
organ_modeled:
name: organ_modeled
description: The organ or anatomical structure being modeled (e.g., lung, airway,
alveolus)
from_schema: https://w3id.org/monarch-initiative/namo
domain_of:
- Organoid
- OrganOnChip
range: GrossAnatomicalStructure
bindings:
- range: OrganEnum
obligation_level: REQUIRED
binds_value_of: id
inlined: true
cell_types:
name: cell_types
description: Cell types present in the organ-on-chip model
from_schema: https://w3id.org/monarch-initiative/namo
domain_of:
- CellularSystem
- OrganOnChip
range: Cell
bindings:
- range: CellTypeEnum
obligation_level: REQUIRED
binds_value_of: id
multivalued: true
inlined_as_list: true
cell_source:
name: cell_source
description: Source of cells (e.g., primary human cells, iPSC-derived, cell line,
patient-derived)
from_schema: https://w3id.org/monarch-initiative/namo
domain_of:
- CellularSystem
- OrganOnChip
name: OrganOnChip
description: 'A model system that simulates the physiological functions of an organ
using a microfluidic device. Examples: Airway-on-chip, ... Aligned with ISO 10991:2023
microfluidics terminology.'
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/82146.html
exact_mappings:
- ISO10991:organ_on_chip
is_a: MicrophysiologicalSystem
attributes:
organ_modeled:
name: organ_modeled
description: The organ or anatomical structure being modeled (e.g., lung, airway,
alveolus)
from_schema: https://w3id.org/monarch-initiative/namo
owner: OrganOnChip
domain_of:
- Organoid
- OrganOnChip
range: GrossAnatomicalStructure
bindings:
- range: OrganEnum
obligation_level: REQUIRED
binds_value_of: id
inlined: true
cell_types:
name: cell_types
description: Cell types present in the organ-on-chip model
from_schema: https://w3id.org/monarch-initiative/namo
owner: OrganOnChip
domain_of:
- CellularSystem
- OrganOnChip
range: Cell
bindings:
- range: CellTypeEnum
obligation_level: REQUIRED
binds_value_of: id
multivalued: true
inlined: true
inlined_as_list: true
cell_source:
name: cell_source
description: Source of cells (e.g., primary human cells, iPSC-derived, cell line,
patient-derived)
from_schema: https://w3id.org/monarch-initiative/namo
owner: OrganOnChip
domain_of:
- CellularSystem
- OrganOnChip
range: string
microfluidic_design:
name: microfluidic_design
description: Detailed design specifications of the microfluidic device
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- MicrophysiologicalSystem
range: MicrofluidicDesign
inlined: true
mechanical_forces:
name: mechanical_forces
description: Mechanical forces applied to the model system
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- MicrophysiologicalSystem
range: MechanicalStimulation
inlined: true
perfusion_system:
name: perfusion_system
description: Description of perfusion and flow systems
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- MicrophysiologicalSystem
range: string
sensor_integration:
name: sensor_integration
description: Sensors integrated for real-time monitoring
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- MicrophysiologicalSystem
range: IntegratedSensorEnum
multivalued: true
biological_organization_level:
name: biological_organization_level
description: The level of biological organization represented by the model
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- NAMModel
range: BiologicalOrganizationLevelEnum
spatial_context:
name: spatial_context
description: Description of spatial organization and context captured by the model
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- NAMModel
range: string
complexity_level:
name: complexity_level
description: Level of biological complexity represented (subcellular, cellular,
tissue, organ, system)
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- NAMModel
range: ComplexityLevelEnum
references:
name: references
description: Literature references that describe, validate, or support this model
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- NAMModel
range: Reference
multivalued: true
inlined: true
inlined_as_list: true
models:
name: models
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
owner: OrganOnChip
domain_of:
- ModelSystem
range: ModelsRelationship
multivalued: true
id:
name: id
description: A unique identifier for a thing
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
slot_uri: schema:identifier
identifier: true
owner: OrganOnChip
domain_of:
- NamedThing
- Reference
- BiolinkEntity
range: uriorcurie
required: true
name:
name: name
description: A human-readable name for a thing
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
slot_uri: schema:name
owner: OrganOnChip
domain_of:
- NamedThing
- BiolinkEntity
range: string
description:
name: description
description: A human-readable description for a thing
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
slot_uri: schema:description
owner: OrganOnChip
domain_of:
- NamedThing
- BiolinkEntity
range: string
type:
name: type
from_schema: https://w3id.org/monarch-initiative/namo
rank: 1000
designates_type: true
owner: OrganOnChip
domain_of:
- NamedThing
range: string