Class: TissueOnChip

Tissue-level microphysiological systems that model specific tissue functions and multi-cellular interactions.

classDiagram class TissueOnChip click TissueOnChip href "../TissueOnChip/" MicrophysiologicalSystem <|-- TissueOnChip click MicrophysiologicalSystem href "../MicrophysiologicalSystem/" TissueOnChip : barrier_functions TissueOnChip : biological_organization_level TissueOnChip --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" TissueOnChip : complexity_level TissueOnChip --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" TissueOnChip : description TissueOnChip : id TissueOnChip : mechanical_forces TissueOnChip --> "0..1" MechanicalStimulation : mechanical_forces click MechanicalStimulation href "../MechanicalStimulation/" TissueOnChip : microfluidic_design TissueOnChip --> "0..1" MicrofluidicDesign : microfluidic_design click MicrofluidicDesign href "../MicrofluidicDesign/" TissueOnChip : models TissueOnChip --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" TissueOnChip : name TissueOnChip : perfusion_system TissueOnChip : references TissueOnChip --> "*" Reference : references click Reference href "../Reference/" TissueOnChip : sensor_integration TissueOnChip --> "*" IntegratedSensorEnum : sensor_integration click IntegratedSensorEnum href "../IntegratedSensorEnum/" TissueOnChip : spatial_context TissueOnChip : tissue_architecture TissueOnChip : tissue_modeled TissueOnChip --> "0..1" Term : tissue_modeled click Term href "../Term/" TissueOnChip : type

Inheritance

NamedThing
- ModelSystem
  - NAMModel
    - MicrophysiologicalSystem
      - TissueOnChip

Slots

Name	Cardinality and Range	Description	Inheritance
tissue_modeled	0..1 Term	The specific tissue being modeled	direct
tissue_architecture	0..1 String	Description of tissue-level architecture and organization	direct
barrier_functions	* String	Tissue barrier functions modeled (epithelial, endothelial, etc	direct
microfluidic_design	0..1 MicrofluidicDesign	Detailed design specifications of the microfluidic device	MicrophysiologicalSystem
mechanical_forces	0..1 MechanicalStimulation	Mechanical forces applied to the model system	MicrophysiologicalSystem
perfusion_system	0..1 String	Description of perfusion and flow systems	MicrophysiologicalSystem
sensor_integration	* IntegratedSensorEnum	Sensors integrated for real-time monitoring	MicrophysiologicalSystem
biological_organization_level	0..1 BiologicalOrganizationLevelEnum	The level of biological organization represented by the model	NAMModel
spatial_context	0..1 String	Description of spatial organization and context captured by the model	NAMModel
complexity_level	0..1 ComplexityLevelEnum	Level of biological complexity represented (subcellular, cellular, tissue, or...	NAMModel
references	* Reference	Literature references that describe, validate, or support this model	NAMModel
models	* ModelsRelationship		ModelSystem
id	1 Uriorcurie	A unique identifier for a thing	NamedThing
name	0..1 String	A human-readable name for a thing	NamedThing
description	0..1 String	A human-readable description for a thing	NamedThing
type	0..1 String		NamedThing

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/monarch-initiative/namo

Mappings

Mapping Type	Mapped Value
self	namo:TissueOnChip
native	namo:TissueOnChip

LinkML Source

Direct

name: TissueOnChip
description: Tissue-level microphysiological systems that model specific tissue functions
  and multi-cellular interactions.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: MicrophysiologicalSystem
attributes:
  tissue_modeled:
    name: tissue_modeled
    description: The specific tissue being modeled
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TissueOnChip
    range: Term
    inlined: true
  tissue_architecture:
    name: tissue_architecture
    description: Description of tissue-level architecture and organization
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TissueOnChip
  barrier_functions:
    name: barrier_functions
    description: Tissue barrier functions modeled (epithelial, endothelial, etc.)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TissueOnChip
    multivalued: true

Induced

name: TissueOnChip
description: Tissue-level microphysiological systems that model specific tissue functions
  and multi-cellular interactions.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: MicrophysiologicalSystem
attributes:
  tissue_modeled:
    name: tissue_modeled
    description: The specific tissue being modeled
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: tissue_modeled
    owner: TissueOnChip
    domain_of:
    - TissueOnChip
    range: Term
    inlined: true
  tissue_architecture:
    name: tissue_architecture
    description: Description of tissue-level architecture and organization
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: tissue_architecture
    owner: TissueOnChip
    domain_of:
    - TissueOnChip
    range: string
  barrier_functions:
    name: barrier_functions
    description: Tissue barrier functions modeled (epithelial, endothelial, etc.)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: barrier_functions
    owner: TissueOnChip
    domain_of:
    - TissueOnChip
    range: string
    multivalued: true
  microfluidic_design:
    name: microfluidic_design
    description: Detailed design specifications of the microfluidic device
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: microfluidic_design
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: MicrofluidicDesign
    inlined: true
  mechanical_forces:
    name: mechanical_forces
    description: Mechanical forces applied to the model system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: mechanical_forces
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: MechanicalStimulation
    inlined: true
  perfusion_system:
    name: perfusion_system
    description: Description of perfusion and flow systems
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: perfusion_system
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: string
  sensor_integration:
    name: sensor_integration
    description: Sensors integrated for real-time monitoring
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: sensor_integration
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: IntegratedSensorEnum
    multivalued: true
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: biological_organization_level
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: spatial_context
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: complexity_level
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: references
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: models
    owner: TissueOnChip
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    alias: id
    owner: TissueOnChip
    domain_of:
    - NamedThing
    - Reference
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: TissueOnChip
    domain_of:
    - NamedThing
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: TissueOnChip
    domain_of:
    - NamedThing
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    alias: type
    owner: TissueOnChip
    domain_of:
    - NamedThing
    range: string