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Class: TissueOnChip

Tissue-level microphysiological systems that model specific tissue functions and multi-cellular interactions. Aligned with ISO 10991:2023 microfluidics terminology.

URI: [namo:TissueOnChip](https://w3id.org/monarch-initiative/namo/TissueOnChip)
classDiagram class TissueOnChip click TissueOnChip href "../TissueOnChip/" MicrophysiologicalSystem <|-- TissueOnChip click MicrophysiologicalSystem href "../MicrophysiologicalSystem/" TissueOnChip : anatomical_structure_modeled TissueOnChip --> "0..1" GrossAnatomicalStructure : anatomical_structure_modeled click GrossAnatomicalStructure href "../GrossAnatomicalStructure/" TissueOnChip : barrier_functions TissueOnChip : biological_organization_level TissueOnChip --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" TissueOnChip : complexity_level TissueOnChip --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" TissueOnChip : description TissueOnChip : id TissueOnChip : mechanical_forces TissueOnChip --> "0..1" MechanicalStimulation : mechanical_forces click MechanicalStimulation href "../MechanicalStimulation/" TissueOnChip : microfluidic_design TissueOnChip --> "0..1" MicrofluidicDesign : microfluidic_design click MicrofluidicDesign href "../MicrofluidicDesign/" TissueOnChip : models TissueOnChip --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" TissueOnChip : name TissueOnChip : perfusion_system TissueOnChip : references TissueOnChip --> "*" Reference : references click Reference href "../Reference/" TissueOnChip : sensor_integration TissueOnChip --> "*" IntegratedSensorEnum : sensor_integration click IntegratedSensorEnum href "../IntegratedSensorEnum/" TissueOnChip : spatial_context TissueOnChip : tissue_architecture TissueOnChip : type
## Inheritance * [NamedThing](NamedThing.md) * [ModelSystem](ModelSystem.md) * [NAMModel](NAMModel.md) * [MicrophysiologicalSystem](MicrophysiologicalSystem.md) * **TissueOnChip** ## Slots | Name | Cardinality and Range | Description | Inheritance | | --- | --- | --- | --- | | [anatomical_structure_modeled](anatomical_structure_modeled.md) | 0..1
[GrossAnatomicalStructure](GrossAnatomicalStructure.md) | The anatomical structure being modeled — a tissue, organ, or other multicellu... | direct | | [tissue_architecture](tissue_architecture.md) | 0..1
[String](String.md) | Description of tissue-level architecture and organization | direct | | [barrier_functions](barrier_functions.md) | *
[String](String.md) | Tissue barrier functions modeled (epithelial, endothelial, etc | direct | | [microfluidic_design](microfluidic_design.md) | 0..1
[MicrofluidicDesign](MicrofluidicDesign.md) | Detailed design specifications of the microfluidic device | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [mechanical_forces](mechanical_forces.md) | 0..1
[MechanicalStimulation](MechanicalStimulation.md) | Mechanical forces applied to the model system | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [perfusion_system](perfusion_system.md) | 0..1
[String](String.md) | Description of perfusion and flow systems | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [sensor_integration](sensor_integration.md) | *
[IntegratedSensorEnum](IntegratedSensorEnum.md) | Sensors integrated for real-time monitoring | [MicrophysiologicalSystem](MicrophysiologicalSystem.md) | | [biological_organization_level](biological_organization_level.md) | 0..1
[BiologicalOrganizationLevelEnum](BiologicalOrganizationLevelEnum.md) | The level of biological organization represented by the model | [NAMModel](NAMModel.md) | | [spatial_context](spatial_context.md) | 0..1
[String](String.md) | Description of spatial organization and context captured by the model | [NAMModel](NAMModel.md) | | [complexity_level](complexity_level.md) | 0..1
[ComplexityLevelEnum](ComplexityLevelEnum.md) | Level of biological complexity represented (subcellular, cellular, tissue, or... | [NAMModel](NAMModel.md) | | [references](references.md) | *
[Reference](Reference.md) | Literature references that describe, validate, or support this model | [NAMModel](NAMModel.md) | | [models](models.md) | *
[ModelsRelationship](ModelsRelationship.md) | | [ModelSystem](ModelSystem.md) | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | A unique identifier for a thing | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | A human-readable name for a thing | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | A human-readable description for a thing | [NamedThing](NamedThing.md) | | [type](type.md) | 0..1
[String](String.md) | | [NamedThing](NamedThing.md) | ## See Also * [https://www.iso.org/standard/82146.html](https://www.iso.org/standard/82146.html) ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/monarch-initiative/namo ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | namo:TissueOnChip | | native | namo:TissueOnChip | | exact | ISO10991:tissue_on_chip | ## LinkML Source ### Direct 
name: TissueOnChip
description: Tissue-level microphysiological systems that model specific tissue functions
  and multi-cellular interactions. Aligned with ISO 10991:2023 microfluidics terminology.
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/82146.html
exact_mappings:
- ISO10991:tissue_on_chip
is_a: MicrophysiologicalSystem
attributes:
  anatomical_structure_modeled:
    name: anatomical_structure_modeled
    description: The anatomical structure being modeled — a tissue, organ, or other
      multicellular structure.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TissueOnChip
    range: GrossAnatomicalStructure
    bindings:
    - range: AnatomicalStructureEnum
      obligation_level: REQUIRED
      binds_value_of: id
    inlined: true
  tissue_architecture:
    name: tissue_architecture
    description: Description of tissue-level architecture and organization
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TissueOnChip
  barrier_functions:
    name: barrier_functions
    description: Tissue barrier functions modeled (epithelial, endothelial, etc.)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TissueOnChip
    multivalued: true
### Induced 
name: TissueOnChip
description: Tissue-level microphysiological systems that model specific tissue functions
  and multi-cellular interactions. Aligned with ISO 10991:2023 microfluidics terminology.
from_schema: https://w3id.org/monarch-initiative/namo
see_also:
- https://www.iso.org/standard/82146.html
exact_mappings:
- ISO10991:tissue_on_chip
is_a: MicrophysiologicalSystem
attributes:
  anatomical_structure_modeled:
    name: anatomical_structure_modeled
    description: The anatomical structure being modeled — a tissue, organ, or other
      multicellular structure.
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - TissueOnChip
    range: GrossAnatomicalStructure
    bindings:
    - range: AnatomicalStructureEnum
      obligation_level: REQUIRED
      binds_value_of: id
    inlined: true
  tissue_architecture:
    name: tissue_architecture
    description: Description of tissue-level architecture and organization
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - TissueOnChip
    range: string
  barrier_functions:
    name: barrier_functions
    description: Tissue barrier functions modeled (epithelial, endothelial, etc.)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - TissueOnChip
    range: string
    multivalued: true
  microfluidic_design:
    name: microfluidic_design
    description: Detailed design specifications of the microfluidic device
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: MicrofluidicDesign
    inlined: true
  mechanical_forces:
    name: mechanical_forces
    description: Mechanical forces applied to the model system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: MechanicalStimulation
    inlined: true
  perfusion_system:
    name: perfusion_system
    description: Description of perfusion and flow systems
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: string
  sensor_integration:
    name: sensor_integration
    description: Sensors integrated for real-time monitoring
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - MicrophysiologicalSystem
    range: IntegratedSensorEnum
    multivalued: true
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    owner: TissueOnChip
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    owner: TissueOnChip
    domain_of:
    - NamedThing
    - Reference
    - BiolinkEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    owner: TissueOnChip
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    owner: TissueOnChip
    domain_of:
    - NamedThing
    - BiolinkEntity
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    owner: TissueOnChip
    domain_of:
    - NamedThing
    range: string