Class: TwoDCellCulture

Conventional monolayer cell cultures grown on flat surfaces. Simple but limited in physiological relevance.

classDiagram class TwoDCellCulture click TwoDCellCulture href "../TwoDCellCulture/" CellularSystem <|-- TwoDCellCulture click CellularSystem href "../CellularSystem/" TwoDCellCulture <|-- CellLineModel click CellLineModel href "../CellLineModel/" TwoDCellCulture : biological_organization_level TwoDCellCulture --> "0..1" BiologicalOrganizationLevelEnum : biological_organization_level click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/" TwoDCellCulture : cell_source TwoDCellCulture : cell_types TwoDCellCulture --> "*" Term : cell_types click Term href "../Term/" TwoDCellCulture : complexity_level TwoDCellCulture --> "0..1" ComplexityLevelEnum : complexity_level click ComplexityLevelEnum href "../ComplexityLevelEnum/" TwoDCellCulture : confluence_level TwoDCellCulture : culture_conditions TwoDCellCulture : description TwoDCellCulture : id TwoDCellCulture : models TwoDCellCulture --> "*" ModelsRelationship : models click ModelsRelationship href "../ModelsRelationship/" TwoDCellCulture : name TwoDCellCulture : passage_protocol TwoDCellCulture : references TwoDCellCulture --> "*" Reference : references click Reference href "../Reference/" TwoDCellCulture : spatial_context TwoDCellCulture : substrate_type TwoDCellCulture : type

Inheritance

NamedThing
- ModelSystem
  - NAMModel
    - CellularSystem
      - TwoDCellCulture
        
        CellLineModel

Slots

Name	Cardinality and Range	Description	Inheritance
substrate_type	0..1 String	Type of culture substrate (e	direct
confluence_level	0..1 Float	Typical confluence level maintained (0	direct
passage_protocol	0..1 String	Standard passaging protocol and frequency	direct
cell_types	* Term	Cell types present in the cellular system	CellularSystem
cell_source	0..1 String	Source of cells (e	CellularSystem
culture_conditions	0..1 String	Standard culture conditions and media used	CellularSystem
biological_organization_level	0..1 BiologicalOrganizationLevelEnum	The level of biological organization represented by the model	NAMModel
spatial_context	0..1 String	Description of spatial organization and context captured by the model	NAMModel
complexity_level	0..1 ComplexityLevelEnum	Level of biological complexity represented (subcellular, cellular, tissue, or...	NAMModel
references	* Reference	Literature references that describe, validate, or support this model	NAMModel
models	* ModelsRelationship		ModelSystem
id	1 Uriorcurie	A unique identifier for a thing	NamedThing
name	0..1 String	A human-readable name for a thing	NamedThing
description	0..1 String	A human-readable description for a thing	NamedThing
type	0..1 String		NamedThing

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/monarch-initiative/namo

Mappings

Mapping Type	Mapped Value
self	namo:TwoDCellCulture
native	namo:TwoDCellCulture

LinkML Source

Direct

name: TwoDCellCulture
description: Conventional monolayer cell cultures grown on flat surfaces. Simple but
  limited in physiological relevance.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: CellularSystem
attributes:
  substrate_type:
    name: substrate_type
    description: Type of culture substrate (e.g., plastic, glass, coated surfaces)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TwoDCellCulture
  confluence_level:
    name: confluence_level
    description: Typical confluence level maintained (0.0-1.0)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TwoDCellCulture
    range: float
  passage_protocol:
    name: passage_protocol
    description: Standard passaging protocol and frequency
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    domain_of:
    - TwoDCellCulture

Induced

name: TwoDCellCulture
description: Conventional monolayer cell cultures grown on flat surfaces. Simple but
  limited in physiological relevance.
from_schema: https://w3id.org/monarch-initiative/namo
is_a: CellularSystem
attributes:
  substrate_type:
    name: substrate_type
    description: Type of culture substrate (e.g., plastic, glass, coated surfaces)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: substrate_type
    owner: TwoDCellCulture
    domain_of:
    - TwoDCellCulture
    range: string
  confluence_level:
    name: confluence_level
    description: Typical confluence level maintained (0.0-1.0)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: confluence_level
    owner: TwoDCellCulture
    domain_of:
    - TwoDCellCulture
    range: float
  passage_protocol:
    name: passage_protocol
    description: Standard passaging protocol and frequency
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: passage_protocol
    owner: TwoDCellCulture
    domain_of:
    - TwoDCellCulture
    range: string
  cell_types:
    name: cell_types
    description: Cell types present in the cellular system
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: cell_types
    owner: TwoDCellCulture
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: Term
    bindings:
    - range: CellTypeEnum
      obligation_level: REQUIRED
      binds_value_of: id
    multivalued: true
    inlined: true
    inlined_as_list: true
  cell_source:
    name: cell_source
    description: Source of cells (e.g., primary, iPSC-derived, immortalized cell lines)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: cell_source
    owner: TwoDCellCulture
    domain_of:
    - CellularSystem
    - OrganOnChip
    range: string
  culture_conditions:
    name: culture_conditions
    description: Standard culture conditions and media used
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: culture_conditions
    owner: TwoDCellCulture
    domain_of:
    - CellularSystem
    range: string
  biological_organization_level:
    name: biological_organization_level
    description: The level of biological organization represented by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: biological_organization_level
    owner: TwoDCellCulture
    domain_of:
    - NAMModel
    range: BiologicalOrganizationLevelEnum
  spatial_context:
    name: spatial_context
    description: Description of spatial organization and context captured by the model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: spatial_context
    owner: TwoDCellCulture
    domain_of:
    - NAMModel
    range: string
  complexity_level:
    name: complexity_level
    description: Level of biological complexity represented (subcellular, cellular,
      tissue, organ, system)
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: complexity_level
    owner: TwoDCellCulture
    domain_of:
    - NAMModel
    range: ComplexityLevelEnum
  references:
    name: references
    description: Literature references that describe, validate, or support this model
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: references
    owner: TwoDCellCulture
    domain_of:
    - NAMModel
    range: Reference
    multivalued: true
    inlined: true
    inlined_as_list: true
  models:
    name: models
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    alias: models
    owner: TwoDCellCulture
    domain_of:
    - ModelSystem
    range: ModelsRelationship
    multivalued: true
  id:
    name: id
    description: A unique identifier for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:identifier
    identifier: true
    alias: id
    owner: TwoDCellCulture
    domain_of:
    - NamedThing
    - Reference
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: TwoDCellCulture
    domain_of:
    - NamedThing
    range: string
  description:
    name: description
    description: A human-readable description for a thing
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: TwoDCellCulture
    domain_of:
    - NamedThing
    range: string
  type:
    name: type
    from_schema: https://w3id.org/monarch-initiative/namo
    rank: 1000
    designates_type: true
    alias: type
    owner: TwoDCellCulture
    domain_of:
    - NamedThing
    range: string