:root {
    --primary: #2563eb;
    --primary-dark: #1d4ed8;
    --primary-light: #dbeafe;
    --bg: #f8fafc;
    --card-bg: #ffffff;
    --border: #e2e8f0;
    --border-strong: #cbd5e1;
    --text: #1e293b;
    --text-muted: #64748b;
    --text-light: #94a3b8;
    --tag-bg: #e0e7ff;
    --tag-text: #3730a3;
    --initial-bg: #dcfce7;
    --initial-text: #166534;
    --expanded-bg: #fef3c7;
    --expanded-text: #92400e;
    --green: #16a34a;
    --green-bg: #f0fdf4;
    --amber: #d97706;
    --amber-bg: #fffbeb;
    --red: #dc2626;
    --red-bg: #fef2f2;
    --shadow-sm: 0 1px 2px rgba(0,0,0,0.05);
    --shadow-md: 0 4px 12px rgba(0,0,0,0.08);
    --radius: 8px;
}

* { box-sizing: border-box; margin: 0; padding: 0; }

body {
    font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, sans-serif;
    background: var(--bg);
    color: var(--text);
    line-height: 1.6;
}

/* Header */
header {
    background: linear-gradient(135deg, #1e3a5f 0%, #2563eb 100%);
    color: white;
    padding: 1.5rem 2rem 1rem;
}

.header-inner {
    max-width: 1200px;
    margin: 0 auto;
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
}

header h1 { font-size: 1.6rem; margin-bottom: 0.15rem; font-weight: 700; }
.subtitle {
    opacity: 0.8;
    font-size: 0.88rem;
    max-width: 900px;
    line-height: 1.5;
    margin-top: 0.4rem;
}

.github-link {
    color: rgba(255,255,255,0.7);
    transition: color 0.2s;
}
.github-link:hover { color: white; }

.header-stats {
    max-width: 1200px;
    margin: 0.75rem auto 0;
    display: flex;
    gap: 1.5rem;
    font-size: 0.85rem;
    opacity: 0.85;
}

.header-stat { display: flex; align-items: center; gap: 0.35rem; }
.header-stat strong { font-weight: 600; }

/* Main */
main { max-width: 1200px; margin: 0 auto; padding: 1.5rem; }

/* Search */
.search-bar {
    display: flex;
    align-items: center;
    gap: 1rem;
    margin-bottom: 1.5rem;
}

.search-wrapper {
    flex: 1;
    position: relative;
}

.search-icon {
    position: absolute;
    left: 0.75rem;
    top: 50%;
    transform: translateY(-50%);
    color: var(--text-light);
    pointer-events: none;
}

#search-input {
    width: 100%;
    padding: 0.75rem 1rem 0.75rem 2.5rem;
    font-size: 1rem;
    border: 2px solid var(--border);
    border-radius: var(--radius);
    outline: none;
    transition: border-color 0.2s, box-shadow 0.2s;
    background: var(--card-bg);
}

#search-input:focus {
    border-color: var(--primary);
    box-shadow: 0 0 0 3px rgba(37,99,235,0.1);
}

.result-count { color: var(--text-muted); white-space: nowrap; font-size: 0.9rem; }

/* Layout */
.content-layout {
    display: grid;
    grid-template-columns: 250px 1fr;
    gap: 1.5rem;
}

/* Filters */
.filters {
    position: sticky;
    top: 1rem;
    align-self: start;
    max-height: calc(100vh - 2rem);
    overflow-y: auto;
    padding-right: 0.5rem;
}

.filters h2 { font-size: 1.05rem; margin-bottom: 1rem; font-weight: 600; }

.filter-group {
    margin-bottom: 1rem;
    padding-bottom: 0.75rem;
    border-bottom: 1px solid var(--border);
}

.filter-group h3 {
    font-size: 0.75rem;
    text-transform: uppercase;
    letter-spacing: 0.06em;
    color: var(--text-muted);
    margin-bottom: 0.4rem;
    font-weight: 600;
}

.filter-group label {
    display: flex;
    align-items: center;
    gap: 0.35rem;
    font-size: 0.85rem;
    cursor: pointer;
    padding: 0.12rem 0;
    line-height: 1.4;
}

.filter-group label:hover { color: var(--primary); }

.filter-group label .count {
    margin-left: auto;
    color: var(--text-light);
    font-size: 0.75rem;
    min-width: 1.5em;
    text-align: right;
}

/* Disease cards */
.disease-card {
    background: var(--card-bg);
    border: 1px solid var(--border);
    border-radius: var(--radius);
    padding: 1.25rem;
    margin-bottom: 0.75rem;
    transition: box-shadow 0.2s, border-color 0.2s;
}

.disease-card:hover {
    box-shadow: var(--shadow-md);
    border-color: var(--border-strong);
}

.card-header {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    gap: 0.75rem;
}

.card-header h3 {
    font-size: 1.05rem;
    font-weight: 600;
    line-height: 1.3;
}

.mondo-id {
    font-family: "SFMono-Regular", Consolas, monospace;
    font-size: 0.8rem;
    color: var(--primary);
    background: var(--primary-light);
    padding: 0.1rem 0.4rem;
    border-radius: 3px;
    white-space: nowrap;
}

.mondo-id a {
    color: inherit;
    text-decoration: none;
}
.mondo-id a:hover { text-decoration: underline; }

.card-badges {
    display: flex;
    flex-wrap: wrap;
    gap: 0.35rem;
    margin-top: 0.5rem;
}

.tag {
    display: inline-block;
    padding: 0.1rem 0.45rem;
    border-radius: 4px;
    font-size: 0.73rem;
    font-weight: 500;
    background: var(--tag-bg);
    color: var(--tag-text);
    line-height: 1.5;
}

.tag.initial { background: var(--initial-bg); color: var(--initial-text); }
.tag.expanded { background: var(--expanded-bg); color: var(--expanded-text); }
.tag.prevalence-h { background: #fee2e2; color: #991b1b; }
.tag.prevalence-l { background: #dbeafe; color: #1e40af; }
.tag.has-treatments { background: var(--green-bg); color: var(--green); }
.tag.has-indications { background: #f0fdf4; color: #15803d; border: 1px solid #bbf7d0; }
.tag.keyword { background: #f1f5f9; color: #475569; }

.card-body { margin-top: 0.6rem; }

.synonyms {
    font-size: 0.82rem;
    color: var(--text-muted);
    font-style: italic;
    margin-bottom: 0.4rem;
    line-height: 1.4;
}

.detail-grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 0.25rem 1.5rem;
    margin-top: 0.4rem;
}

.detail-row {
    font-size: 0.82rem;
    color: var(--text-muted);
    line-height: 1.5;
}

.detail-row strong {
    color: var(--text);
    font-weight: 500;
}

.detail-row.full-width {
    grid-column: 1 / -1;
}

/* Categories block */
.categories-block {
    margin-top: 0.4rem;
    display: flex;
    flex-direction: column;
    gap: 0.3rem;
}

.category-section {
    display: flex;
    align-items: baseline;
    gap: 0.4rem;
}

.category-label {
    font-size: 0.72rem;
    font-weight: 600;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.04em;
    min-width: 5.5em;
    flex-shrink: 0;
}

/* Category pills (SimpleTerm linked) */
.category-list {
    display: flex;
    flex-wrap: wrap;
    gap: 0.25rem;
}

.category-pill {
    display: inline-flex;
    align-items: center;
    gap: 0.3rem;
    font-size: 0.72rem;
    padding: 0.1rem 0.45rem;
    border-radius: 3px;
    background: #f1f5f9;
    color: #475569;
    border: 1px solid var(--border);
    text-decoration: none;
    transition: border-color 0.15s, background 0.15s;
}

a.category-pill:hover {
    border-color: var(--primary);
    background: var(--primary-light);
    color: var(--primary-dark);
}

.category-pill.mondo { border-left: 2px solid var(--primary); }
.category-pill.hpo { border-left: 2px solid #8b5cf6; }
.category-pill.histopheno { border-left: 2px solid #f59e0b; }

.pill-id {
    font-family: "SFMono-Regular", Consolas, monospace;
    font-size: 0.65rem;
    color: var(--text-light);
    opacity: 0.7;
}

a.category-pill:hover .pill-id { opacity: 1; color: var(--primary); }

/* CURIE links */
.curie-link {
    font-family: "SFMono-Regular", Consolas, monospace;
    font-size: 0.78rem;
    color: var(--primary);
    text-decoration: none;
}

.curie-link:hover { text-decoration: underline; }

.curie-nolink {
    font-family: "SFMono-Regular", Consolas, monospace;
    font-size: 0.78rem;
    color: var(--text-muted);
}

/* Cross-references section */
.xrefs-section {
    font-size: 0.82rem;
    margin-top: 0.4rem;
    line-height: 1.8;
    color: var(--text-muted);
}

.xrefs-section strong { color: var(--text); font-weight: 500; }

/* Jurisdiction label */
.jurisdiction {
    font-size: 0.75rem;
    color: var(--text-muted);
}

/* Inline term links (for MONDO HL categories, HPO profiles) */
.term-link {
    text-decoration: none;
    font-size: inherit;
    border-bottom: 1px dotted var(--text-light);
    transition: border-color 0.15s, color 0.15s;
}

.term-link.mondo { color: var(--primary); }
.term-link.hpo { color: #7c3aed; }
.term-link:hover { border-bottom-style: solid; }
.term-link.mondo:hover { color: var(--primary-dark); }
.term-link.hpo:hover { color: #6d28d9; }

.term-nolink {
    font-size: inherit;
    color: var(--text-muted);
}

/* CSS tooltips */
.tooltip-wrap {
    position: relative;
    cursor: help;
    text-decoration: underline dotted;
    text-underline-offset: 2px;
}

.tooltip-text {
    display: none;
    position: absolute;
    bottom: calc(100% + 6px);
    left: 50%;
    transform: translateX(-50%);
    background: var(--text);
    color: white;
    font-size: 0.72rem;
    font-weight: 400;
    line-height: 1.4;
    padding: 0.4rem 0.6rem;
    border-radius: 4px;
    white-space: normal;
    width: max-content;
    max-width: 280px;
    z-index: 100;
    pointer-events: none;
    box-shadow: 0 2px 8px rgba(0,0,0,0.15);
}

.tooltip-text::after {
    content: "";
    position: absolute;
    top: 100%;
    left: 50%;
    transform: translateX(-50%);
    border: 5px solid transparent;
    border-top-color: var(--text);
}

.tooltip-wrap:hover .tooltip-text {
    display: block;
}

/* Search match highlight */
mark.search-match {
    background: #fef08a;
    color: inherit;
    padding: 0 1px;
    border-radius: 2px;
}

.match-indicator {
    font-size: 0.75rem;
    color: var(--text-muted);
    background: #fefce8;
    border: 1px solid #fde68a;
    border-radius: 4px;
    padding: 0.25rem 0.5rem;
    margin-bottom: 0.5rem;
    line-height: 1.4;
}

.match-indicator strong { color: var(--text); }

/* Card subsections (HPO profiles etc.) */
.card-subsection {
    margin-top: 0.5rem;
    padding-top: 0.4rem;
}

.subsection-label {
    display: block;
    font-size: 0.78rem;
    font-weight: 600;
    color: var(--text);
    margin-bottom: 0.3rem;
}

/* Collapsible sections */
.card-section {
    margin-top: 0.75rem;
    border-top: 1px solid var(--border);
    padding-top: 0.6rem;
}

.section-toggle {
    display: flex;
    align-items: center;
    gap: 0.4rem;
    cursor: pointer;
    background: none;
    border: none;
    font-size: 0.82rem;
    font-weight: 600;
    color: var(--text);
    padding: 0.2rem 0;
    width: 100%;
    text-align: left;
}

.section-toggle:hover { color: var(--primary); }

.section-toggle .arrow {
    transition: transform 0.2s;
    font-size: 0.7rem;
}

.section-toggle.open .arrow { transform: rotate(90deg); }

.section-content {
    display: none;
    padding-top: 0.4rem;
}

.section-content.open { display: block; }

/* Treatment / indication entries */
.drug-entry {
    margin-bottom: 0.6rem;
    padding: 0.6rem 0.75rem;
    background: var(--bg);
    border-radius: 6px;
    border: 1px solid var(--border);
}

.drug-entry:last-child { margin-bottom: 0; }

.drug-header {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    margin-bottom: 0.3rem;
}

.drug-name {
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--text);
}

.drug-id {
    font-family: monospace;
    font-size: 0.72rem;
    color: var(--text-muted);
    background: var(--card-bg);
    padding: 0.05rem 0.3rem;
    border-radius: 3px;
    border: 1px solid var(--border);
}

.evidence-item {
    font-size: 0.78rem;
    color: var(--text-muted);
    padding: 0.3rem 0;
    border-top: 1px dashed var(--border);
    line-height: 1.5;
}

.evidence-item:first-child { border-top: none; }

.evidence-meta {
    display: flex;
    gap: 0.5rem;
    align-items: center;
    margin-bottom: 0.15rem;
}

.evidence-badge {
    font-size: 0.68rem;
    padding: 0.05rem 0.35rem;
    border-radius: 3px;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.03em;
}

.evidence-badge.literature { background: #ede9fe; color: #5b21b6; }
.evidence-badge.database { background: #e0f2fe; color: #0369a1; }
.evidence-badge.regulatory { background: var(--green-bg); color: var(--green); }

.confidence-badge {
    font-size: 0.68rem;
    padding: 0.05rem 0.35rem;
    border-radius: 3px;
    font-weight: 500;
}

.confidence-badge.medium { background: var(--amber-bg); color: var(--amber); }
.confidence-badge.low { background: var(--red-bg); color: var(--red); }
.confidence-badge.high { background: var(--green-bg); color: var(--green); }

.evidence-ref {
    font-family: monospace;
    font-size: 0.72rem;
    color: var(--primary);
    word-break: break-all;
}

.evidence-ref a {
    color: inherit;
    text-decoration: none;
}
.evidence-ref a:hover { text-decoration: underline; }

.evidence-text {
    font-size: 0.78rem;
    color: var(--text-muted);
    margin-top: 0.15rem;
    line-height: 1.5;
}

/* Evidence cards (rich display) */
.evidence-card {
    margin-top: 0.4rem;
    padding: 0.5rem 0.65rem;
    background: var(--card-bg);
    border: 1px solid var(--border);
    border-radius: 5px;
    font-size: 0.78rem;
    line-height: 1.5;
}

.evidence-card + .evidence-card { margin-top: 0.3rem; }

.evidence-top-row {
    display: flex;
    justify-content: space-between;
    align-items: center;
    gap: 0.4rem;
    flex-wrap: wrap;
}

.evidence-top-left {
    display: flex;
    flex-wrap: wrap;
    align-items: center;
    gap: 0.3rem;
}

.evidence-jurisdiction {
    font-size: 0.7rem;
    font-weight: 600;
    color: #475569;
    background: #f1f5f9;
    padding: 0.05rem 0.35rem;
    border-radius: 3px;
    border: 1px solid var(--border);
}

.approval-badge {
    font-size: 0.68rem;
    padding: 0.05rem 0.35rem;
    border-radius: 3px;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.03em;
    background: var(--green-bg);
    color: var(--green);
}

.approval-badge.investigational { background: var(--amber-bg); color: var(--amber); }
.approval-badge.withdrawn, .approval-badge.discontinued { background: var(--red-bg); color: var(--red); }
.approval-badge.off_label { background: #ede9fe; color: #5b21b6; }

.phase-badge {
    font-size: 0.68rem;
    padding: 0.05rem 0.35rem;
    border-radius: 3px;
    font-weight: 500;
    text-transform: capitalize;
    background: #f0f9ff;
    color: #0369a1;
    border: 1px solid #bae6fd;
}

.evidence-source-badge {
    font-size: 0.65rem;
    padding: 0.05rem 0.3rem;
    border-radius: 3px;
    color: var(--text-muted);
    background: #f8fafc;
    border: 1px solid var(--border);
    text-transform: capitalize;
}

/* Confidence group: D / Dx / A indicators */
.confidence-group {
    display: inline-flex;
    gap: 0.15rem;
    align-items: center;
}

.conf-dot {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    width: 1.4em;
    height: 1.2em;
    font-size: 0.6rem;
    font-weight: 700;
    border-radius: 2px;
    cursor: help;
    line-height: 1;
}

.conf-dot.high { background: var(--green-bg); color: var(--green); border: 1px solid #bbf7d0; }
.conf-dot.medium { background: var(--amber-bg); color: var(--amber); border: 1px solid #fde68a; }
.conf-dot.low { background: var(--red-bg); color: var(--red); border: 1px solid #fecaca; }

.conf-dot.tooltip-wrap { text-decoration: none; }
.conf-dot .tooltip-text { left: 50%; bottom: calc(100% + 4px); white-space: nowrap; }

.support-badge {
    font-size: 0.65rem;
    padding: 0.05rem 0.3rem;
    border-radius: 3px;
    font-weight: 600;
    text-transform: uppercase;
}

.support-badge.support { background: var(--green-bg); color: var(--green); }
.support-badge.refute { background: var(--red-bg); color: var(--red); }
.support-badge.partial { background: var(--amber-bg); color: var(--amber); }
.support-badge.no_evidence { background: #f1f5f9; color: var(--text-muted); }

/* Reference line */
.evidence-ref-line {
    margin-top: 0.3rem;
    display: flex;
    flex-wrap: wrap;
    align-items: baseline;
    gap: 0.4rem;
}

.evidence-ref-title {
    font-size: 0.76rem;
    color: var(--text);
    font-style: italic;
}

/* Source description and URL */
.evidence-source-desc {
    font-size: 0.72rem;
    color: var(--text-light);
    margin-top: 0.2rem;
    font-style: italic;
}

.evidence-source-url {
    font-size: 0.7rem;
    margin-top: 0.1rem;
}

.evidence-source-url a {
    color: var(--primary);
    text-decoration: none;
    word-break: break-all;
}

.evidence-source-url a:hover { text-decoration: underline; }

/* Snippet */
.evidence-snippet {
    margin-top: 0.3rem;
    padding: 0.4rem 0.5rem;
    background: #fefce8;
    border-left: 3px solid #fbbf24;
    border-radius: 0 4px 4px 0;
    font-size: 0.76rem;
    color: var(--text);
    line-height: 1.55;
    white-space: pre-wrap;
}

/* Explanation */
.evidence-explanation {
    margin-top: 0.25rem;
    font-size: 0.76rem;
    color: var(--text-muted);
    line-height: 1.5;
}

/* Curator */
.evidence-curator {
    margin-top: 0.25rem;
    font-size: 0.68rem;
    color: var(--text-light);
}

.curator-type {
    display: inline-block;
    font-size: 0.62rem;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.03em;
    background: #f1f5f9;
    color: var(--text-muted);
    padding: 0.02rem 0.25rem;
    border-radius: 2px;
    margin-right: 0.3rem;
}

/* Feedback button */
.feedback-btn {
    flex-shrink: 0;
    background: none;
    border: 1px solid transparent;
    border-radius: 4px;
    padding: 0.2rem;
    cursor: pointer;
    color: var(--text-light);
    transition: color 0.15s, border-color 0.15s, background 0.15s;
    line-height: 1;
}

.feedback-btn:hover {
    color: var(--red);
    border-color: var(--red);
    background: var(--red-bg);
}

/* Feedback form (hidden by default) */
.feedback-form {
    display: none;
    margin-top: 0.4rem;
    padding-top: 0.4rem;
    border-top: 1px dashed var(--border);
}

.feedback-form.open { display: block; }

.feedback-text {
    width: 100%;
    font-size: 0.78rem;
    font-family: inherit;
    padding: 0.4rem;
    border: 1px solid var(--border);
    border-radius: 4px;
    resize: vertical;
    outline: none;
}

.feedback-text:focus {
    border-color: var(--primary);
    box-shadow: 0 0 0 2px rgba(37,99,235,0.1);
}

.feedback-actions {
    display: flex;
    gap: 0.4rem;
    margin-top: 0.3rem;
}

.feedback-submit {
    font-size: 0.75rem;
    padding: 0.3rem 0.6rem;
    border: none;
    border-radius: 4px;
    background: var(--primary);
    color: white;
    cursor: pointer;
    font-weight: 500;
}

.feedback-submit:hover { background: var(--primary-dark); }

.feedback-cancel {
    font-size: 0.75rem;
    padding: 0.3rem 0.6rem;
    border: 1px solid var(--border);
    border-radius: 4px;
    background: var(--card-bg);
    color: var(--text-muted);
    cursor: pointer;
}

.feedback-cancel:hover { border-color: var(--text-muted); }

.evidence-text.truncated { cursor: pointer; }
.evidence-text.truncated:hover { color: var(--text); }

/* Nested MONDO high-level sub-categories */
.mondo-hl-nested {
    margin-top: 0.25rem;
    padding-left: 0.25rem;
    display: flex;
    flex-direction: column;
    gap: 0.2rem;
}

.mondo-hl-row {
    display: flex;
    align-items: baseline;
    gap: 0.3rem;
    flex-wrap: wrap;
}

.mondo-hl-label {
    font-size: 0.68rem;
    font-weight: 500;
    color: var(--text-light);
    min-width: 6em;
    flex-shrink: 0;
}

/* Pagination */
.pagination {
    display: flex;
    justify-content: center;
    align-items: center;
    gap: 0.3rem;
    margin-top: 1.5rem;
    padding-bottom: 1rem;
}

.pagination button {
    padding: 0.35rem 0.7rem;
    border: 1px solid var(--border);
    border-radius: 4px;
    background: var(--card-bg);
    cursor: pointer;
    font-size: 0.85rem;
    color: var(--text);
    transition: all 0.15s;
}

.pagination button:hover {
    border-color: var(--primary);
    color: var(--primary);
}

.pagination button.active {
    background: var(--primary);
    color: white;
    border-color: var(--primary);
}

.pagination .ellipsis {
    padding: 0.35rem 0.3rem;
    color: var(--text-light);
    font-size: 0.85rem;
}

/* Footer */
footer {
    text-align: center;
    padding: 1.5rem 2rem;
    color: var(--text-muted);
    font-size: 0.82rem;
    border-top: 1px solid var(--border);
}

footer a { color: var(--primary); text-decoration: none; }
footer a:hover { text-decoration: underline; }

/* Loading */
.loading {
    text-align: center;
    padding: 3rem;
    color: var(--text-muted);
    font-size: 1rem;
}

/* Responsive */
@media (max-width: 768px) {
    .content-layout { grid-template-columns: 1fr; }
    .filters { position: static; max-height: none; padding-right: 0; }
    .detail-grid { grid-template-columns: 1fr; }
    .mondo-hl { grid-template-columns: 1fr; }
    .header-inner { flex-direction: column; gap: 0.5rem; }
    .header-stats { flex-wrap: wrap; }
}